DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and RBOHD

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_199602.1	Gene:	RBOHD / 834842	AraportID:	AT5G47910	Length:	921	Species:	Arabidopsis thaliana

Alignment Length:	855	Identity:	217/855 - (25%)
Similarity:	377/855 - (44%)	Gaps:	122/855 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   768 LED--FLLLHKKEMTLMEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPGERRRRSDASS 830
            |||  ..||.||.:. ..:|....|:...:...|.|......|.    .|..||....||.|.:|
plant   103 LEDPELALLTKKTLE-SSLNNTTSLSFFRSTSSRIKNASRELRR----VFSRRPSPAVRRFDRTS 162

  Fly   831 DGEV-------MTVMRTS-------------------LSKAEFAAALGM-KPNDMFVRKMF---- 864
            ...:       ....:|:                   |..|:|...||| |.:..|..::|
plant   163 SAAIHALKGLKFIATKTAAWPAVDQRFDKLSADSNGLLLSAKFWECLGMNKESKDFADQLFRALA 227

  Fly   865 --NIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIA 927
              |.|..|...:...:.|.|.:   |....|.||::.|||.|.|.:|.:.:.|::|:: ||...|
plant   228 RRNNVSGDAITKEQLRIFWEQI---SDESFDAKLQVFFDMVDKDEDGRVTEEEVAEII-SLSASA 288

  Fly   928 RTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTN 992
            ...|....|..|....:.:::..::...:..::.::::.:.....|.:|            .|..
plant   289 NKLSNIQKQAKEYAALIMEELDPDNAGFIMIENLEMLLLQAPNQSVRMG------------DSRI 341

  Fly   993 VARMTSFNIEPMQD-KPRHWLLAKWDAYIT-FLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMA 1055
            :::|.|..:.|.:: .|    |.:|...|. |:.:|.|.::.:.|:..:...||..:||.|...|
plant   342 LSQMLSQKLRPAKESNP----LVRWSEKIKYFILDNWQRLWIMMLWLGICGGLFTYKFIQYKNKA 402

  Fly  1056 EHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLK-EFPIQQYIPLDSHIQFHKIAA 1119
            .:    .:||..:.:.:|.|.:|.|..:|:||.:.||.||.|: :..:...:|.|..:.|||:.|
plant   403 AY----GVMGYCVCVAKGGAETLKFNMALILLPVCRNTITWLRNKTKLGTVVPFDDSLNFHKVIA 463

  Fly  1120 CTALFFSVLHTVGHIV-NFYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFI 1183
            ...:...:||...|:. :|..:.....:....:  |.:|..  :|...:|..:.|.|.||:::.:
plant   464 SGIVVGVLLHAGAHLTCDFPRLIAADEDTYEPM--EKYFGD--QPTSYWWFVKGVEGWTGIVMVV 524

  Fly  1184 IMCIIFVFAHPTIRKK------------AYNFFWNMHTLYIGLYLLSLIHG----LARLTGPPRF 1232
            :|.|.|..|.|..|:.            .:|.||..|.|:|.:|.|.::||    |.::......
plant   525 LMAIAFTLATPWFRRNKLNLPNFLKKLTGFNAFWYTHHLFIIVYALLIVHGIKLYLTKIWYQKTT 589

  Fly  1233 WMFFLGPGIVYTLDKIV-SLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAF 1296
            ||:...|.::|..:::: :.|:....:.:|...:.|.:|:.:...:|...||.|||::.::|.|.
plant   590 WMYLAVPILLYASERLLRAFRSSIKPVKMIKVAVYPGNVLSLHMTKPQGFKYKSGQFMLVNCRAV 654

  Fly  1297 RPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPE----------------DQPK 1345
            .|.|.|.|::||||.:::||.||:..|.||.|||..|......|.                ..||
plant   655 SPFEWHPFSITSAPGDDYLSVHIRTLGDWTRKLRTVFSEVCKPPTAGKSGLLRADGGDGNLPFPK 719

  Fly  1346 IRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLV-------------FGTSTNRYSGVA 1397
            :.|:||:|...||:.|::|.::||.|||.||..|||.|::             ...|.|...|..
plant   720 VLIDGPYGAPAQDYKKYDVVLLVGLGIGATPMISILKDIINNMKGPDRDSDIENNNSNNNSKGFK 784

  Fly  1398 CKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRL 1462
            .:|.||.|:......||||..::.::.:.|...::|:|.:.|..:.:.|.|..::.:.::.....
plant   785 TRKAYFYWVTREQGSFEWFKGIMDEISELDEEGIIELHNYCTSVYEEGDARVALIAMLQSLQHAK 849

  Fly  1463 SKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMS-ACDEVNKTRKL 1526
            :...:.:|.:..:||.:|:.....|.:..:|. ..:||||.||...:.|.:.: |.|...||  .
plant   850 NGVDVVSGTRVKSHFAKPNWRQVYKKIAVQHP-GKRIGVFYCGMPGMIKELKNLALDFSRKT--T 911

  Fly  1527 PYFIHHFENF 1536
            ..|..|.|||
plant   912 TKFDFHKENF 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	16/87 (18%)
		EFh	860..921	CDD:238008	18/66 (27%)
		EF-hand_7	860..920	CDD:290234	18/65 (28%)
		EFh	895..966	CDD:238008	16/70 (23%)
		EF-hand_7	899..965	CDD:290234	14/65 (22%)
		Ferric_reduct	1084..1217	CDD:280043	39/146 (27%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	88/300 (29%)
RBOHD	NP_199602.1	NADPH_Ox	161..255	CDD:285598	17/96 (18%)
		EFh	<237..283	CDD:238008	14/49 (29%)
		Ferric_reduct	424..571	CDD:280043	39/150 (26%)
		NOX_Duox_like_FAD_NADP	619..921	CDD:99783	89/304 (29%)
		NAD_binding_6	736..903	CDD:285298	42/167 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I3552
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm2409
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	1	1.100	-	-	O	PTHR11972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810