DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and FRO5

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001330174.1	Gene:	FRO5 / 832464	AraportID:	AT5G23990	Length:	699	Species:	Arabidopsis thaliana

Alignment Length:	477	Identity:	112/477 - (23%)
Similarity:	205/477 - (42%)	Gaps:	70/477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1036 FYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASL------SFCYSLLLLTMSRNLI 1094
            |.::.:.|.|....:|.:::.|..|.:.....|...:..|..|      .:|::.|...::|
plant   112 FSLLFLALLVWALSNYLYLSYHVHLHNHDNAKIWQAKFRAFGLRIGYVGHYCWAFLFFPVTR--- 173

  Fly  1095 TKLKEFPIQQYIPL-----DSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTRE 1154
                   ....:||     :|.|::|......:.|..::|||..:
plant   174 -------ASTILPLVGLTSESSIKYHIWLGHVSNFCFLVHTVVFL-------------------- 211

  Fly  1155 VHFASDYKPDITF-WLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLL- 1217
            :::|...|...|| |....|....|.:..:|...|:|.:.|:.|:|.:..|:..|.|| |||::
plant   212 IYWAMVNKLMETFAWNATYVPNLAGTIAMVIGIAIWVTSLPSFRRKKFEIFFYTHHLY-GLYIVF 275

  Fly  1218 SLIHGLARLTGPPRFWMFFLGPGI-VYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNL 1281
            ..||     .|..  |...:.|.| ::.:|:.:..........::...:||||.:::.|.:...|
plant   276 YAIH-----VGDS--WFCMILPNIFLFFIDRYLRFLQSTKRSRLVSAKILPSDNLELTFAKTSGL 333

  Fly  1282 KYLSGQWVRLSCTAFRPHEMHSFTLTSAPH--ENFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQP 1344
            .|.....:.|...:....:.|.||:||:.:  ::.||..|:.||.||.||..:..    :..|..
plant   334 HYTPTSILFLHVPSISKLQWHPFTITSSSNLEKDTLSVVIRKQGSWTQKLYTHLS----SSIDSL 394

  Fly  1345 KIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICP- 1408
            ::..|||:|..:.|..:.:..::||||.||||:.|::.:|:| .|.||    :.|....|.:|.
plant   395 EVSTEGPYGPNSFDVSRHDSLILVGGGSGVTPFISVIRELIF-QSQNR----STKLPNVLLVCAF 454

  Fly  1409 SHKHFEWFIDVL--RDVEKKDVTNV-LEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTG 1470
            .:.|...|:|::  .|:...|::.: |.|..:||:...|.:.......:....|:.....|..:.
plant   455 KNYHDLAFLDLIFPSDISVSDISKLNLRIEAYITREDKKPETTDDHKLLQTKWFKPQPLDSPISP 519

  Fly  1471 LKAVNHF---GRPDMSSFLKFV 1489
            :...|:|   |...:|||:.|:
plant   520 VLGPNNFLWLGVVILSSFVMFL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	31/138 (22%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	64/234 (27%)
FRO5	NP_001330174.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810