DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and FRO4

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_197786.2	Gene:	FRO4 / 832463	AraportID:	AT5G23980	Length:	699	Species:	Arabidopsis thaliana

Alignment Length:	496	Identity:	122/496 - (24%)
Similarity:	209/496 - (42%)	Gaps:	108/496 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1060 LRHIMGVGIAITR--GSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFH------- 1115
            |:.|||..|.:..  |...:....:|||.:.        |..:.:..|:.|..|:..|
plant    88 LKRIMGRVIMVMNPLGIVTATELTFSLLFVA--------LLAWSLYNYLYLSYHVHLHNDDNAKI 144

  Fly  1116 ---KIAA-----------CTA-LFFSVLH--TVGHIVNF-------YHVSTQSHENLRCLTREVH 1156
               |..|           |.| |||.|..  |:..:|..       ||:......|...|...|.
plant   145 WQAKFRAFGLRIGYVGNICWAFLFFPVTRASTILPLVGLTSESSIKYHIWLGHVSNFCFLVHTVV 209

  Fly  1157 FASDYKPDITFW-----LFQT-------VTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHT 1209
            |       :.:|     |.:|       |....|.:..:|...::|.:.|:.|:|.:..|:..|.
plant   210 F-------LIYWAMINKLMETFAWNPTYVPNLAGTIAMVIGIAMWVTSLPSFRRKKFEIFFYTHH 267

  Fly  1210 LYIGLYLL-SLIHGLARLTGPPRFWMFFLGPGI-VYTLDKIVSLRTKYMALDVIDTDLLPSDVIK 1272
            || |||:: .:||     .|..  |...:.|.| ::.:|:.:..........::...:||||.::
plant   268 LY-GLYIVFYVIH-----VGDS--WFCMILPNIFLFFIDRYLRFLQSTKRSRLVSARILPSDNLE 324

  Fly  1273 IKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPH--ENFLSCHIKAQGPWTWKLRNYFDP 1335
            :.|.:.|.|.|.....:.|...:....:.|.||:||:.:  ::.||..|:.||.||.||..:..
plant   325 LTFSKTPGLHYTPTSILFLHVPSISKIQWHPFTITSSSNLEKDTLSVVIRRQGSWTQKLYTHLS- 388

  Fly  1336 CNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKK 1400
               :..|..::..|||:|..:.|..:....::|.||.|:||:.|::.:|: ..|.|:    :.|.
plant   389 ---SSIDSLEVSTEGPYGPNSFDVSRHNSLILVSGGSGITPFISVIRELI-SQSQNK----STKL 445

  Fly  1401 VYFLWICPSHKHFE--WFIDVL--RDVEKKDVTNV-LEIHIFITQFFHKFDLRTTMLYICENHFQ 1460
            ...|.:| |.||:.  .|:|::  .|:...|::.: |.|..:||:...|.:  ||     ::|
plant   446 PDVLLVC-SFKHYHDLAFLDLIFPLDMSASDISRLNLRIEAYITREDKKPE--TT-----DDH-- 500

  Fly  1461 RLSKTSIF---------TGLKAVNHF---GRPDMSSFLKFV 1489
            ||.:|..|         :.:...|:|   |...:|||:.|:
plant   501 RLLQTKWFKPQPLDSPISPVLGPNNFLWLGVVILSSFVMFL 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	40/175 (23%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	68/244 (28%)
FRO4	NP_197786.2	PLN02631	1..699	CDD:178238	122/496 (25%)
		Ferric_reduct	159..275	CDD:280043	31/123 (25%)
		NOX_Duox_like_FAD_NADP	312..489	CDD:99783	52/186 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810