DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and RBOHA

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_196356.1	Gene:	RBOHA / 830630	AraportID:	AT5G07390	Length:	902	Species:	Arabidopsis thaliana

Alignment Length:	783	Identity:	205/783 - (26%)
Similarity:	364/783 - (46%)	Gaps:	121/783 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 VMTVMRTS--LSKAEFAAALGMKPNDMFVRKMFNIVDKDQD---GRISFQEFLETVVLFSRGKTD 893
            ||| |.|:  |.::.|...:|||..: |...:|:.:.:.::   ..|:..|..|.....:....|
plant   161 VMT-MTTNGLLHRSRFGECIGMKSTE-FALALFDALARRENVSGDSININELKEFWKQITDQDFD 223

  Fly   894 DKLRIIFDMCDNDRNGVIDKGELSEMM------RSLVEIARTTSLGDDQVTELIDGMFQDVGLEH 952
            .:||..|.|.|.|.:|.:::.|:.|::      ..|..|.|..    |:...||   .:::...|
plant   224 SRLRTFFAMVDKDSDGRLNEAEVREIITLSASANELDNIRRQA----DEYAALI---MEELDPYH 281

  Fly   953 KNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVARMTSFNIEPMQDKPRHWLLAKWD 1017
            ..::..::.::::.:.....|.   |.:|.|         :::|.|.|:...|.:.......:..
plant   282 YGYIMIENLEILLLQAPMQDVR---DGEGKK---------LSKMLSQNLMVPQSRNLGARFCRGM 334

  Fly  1018 AYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCY 1082
            .|  ||.:|.:.::.:.|:......||..:|:.|...:.:    .:|||.:.|.:|:|.:|....
plant   335 KY--FLFDNWKRVWVMALWIGAMAGLFTWKFMEYRKRSAY----EVMGVCVCIAKGAAETLKLNM 393

  Fly  1083 SLLLLTMSRNLITKLK-EFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIV-NFYHVSTQSH 1145
            :::||.:.||.||.|: :..:...:|.|..:.|||:.|........:|...|:. :|..:.....
plant   394 AMILLPVCRNTITWLRTKTKLSAIVPFDDSLNFHKVIAIGISVGVGIHATSHLACDFPRLIAADE 458

  Fly  1146 ENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKK----------- 1199
            :....:  |.:|....|..:.|  .|:|.|.||:.:.::|.|.|..|....|:.
plant   459 DQYEPM--EKYFGPQTKRYLDF--VQSVEGVTGIGMVVLMTIAFTLATTWFRRNKLNLPGPLKKI 519

  Fly  1200 -AYNFFWNMHTLYIGLYLLSLIHGL-ARLTGPPRF----WMFFLGPGIVYTLDKIV-SLRTKYMA 1257
             .:|.||..|.|::.:|.|.::||. ..|...|.:    ||:.:.|.::|..:::: :.|:...|
plant   520 TGFNAFWYSHHLFVIVYSLLVVHGFYVYLIIEPWYKKTTWMYLMVPVVLYLCERLIRAFRSSVEA 584

  Fly  1258 LDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQ 1322
            :.|:...:||.:|:.:...||.|.:|.|||::.|:|:|....|.|.|::||||.:::||.||:..
plant   585 VSVLKVAVLPGNVLSLHLSRPSNFRYKSGQYMYLNCSAVSTLEWHPFSITSAPGDDYLSVHIRVL 649

  Fly  1323 GPWTWKLRNYF-DPCNYNPEDQ-----------------PKIRIEGPFGGGNQDWYKFEVAVMVG 1369
            |.||.:||:.| :.|...|.|:                 |:|.|:||:|...||:.||||.::||
plant   650 GDWTKQLRSLFSEVCKPRPPDEHRLNRADSKHWDYIPDFPRILIDGPYGAPAQDYKKFEVVLLVG 714

  Fly  1370 GGIGVTPYASILNDLVFGTSTNRYSGV----------------------------ACKKVYFLWI 1406
            .|||.||..||::|::     |...||                            ..|:.||.|:
plant   715 LGIGATPMISIVSDII-----NNLKGVEEGSNRRQSPIHNMVTPPVSPSRKSETFRTKRAYFYWV 774

  Fly  1407 CPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICE--NHFQRLSKTSIFT 1469
            ......|:||.:|:.:|.:.|..||:|:|.:.|..:.:.|.|:.::.:.:  ||.:.  ...:.:
plant   775 TREQGSFDWFKNVMDEVTETDRKNVIELHNYCTSVYEEGDARSALITMLQSLNHAKH--GVDVVS 837

  Fly  1470 GLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMS-ACDEVNKTRKLPYFIHHF 1533
            |.:.::||.||:..|..|.:...|. .:::|||.||...|.|.:.. :.|..:||.  ..||.|.
plant   838 GTRVMSHFARPNWRSVFKRIAVNHP-KTRVGVFYCGAAGLVKELRHLSLDFSHKTS--TKFIFHK 899

  Fly  1534 ENF 1536
            |||
plant   900 ENF 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	14/52 (27%)
		EFh	860..921	CDD:238008	14/69 (20%)
		EF-hand_7	860..920	CDD:290234	14/62 (23%)
		EFh	895..966	CDD:238008	16/76 (21%)
		EF-hand_7	899..965	CDD:290234	14/71 (20%)
		Ferric_reduct	1084..1217	CDD:280043	36/146 (25%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	99/319 (31%)
RBOHA	NP_196356.1	NADPH_Ox	129..223	CDD:285598	15/63 (24%)
		Ferric_reduct	391..539	CDD:280043	36/151 (24%)
		FAD_binding_8	583..701	CDD:285293	41/117 (35%)
		NAD_binding_6	707..884	CDD:285298	50/184 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	78	1.000	Domainoid score	I3057
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm2409
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	1	1.100	-	-	O	PTHR11972
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.810