DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Duox and AT3G45810

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_190167.2	Gene:	AT3G45810 / 823724	AraportID:	AT3G45810	Length:	912	Species:	Arabidopsis thaliana

Alignment Length:	872	Identity:	217/872 - (24%)
Similarity:	352/872 - (40%)	Gaps:	213/872 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   818 RPGERRRRSDASSDGEVMTVMR---------------------------TSLSKAEFAAALGMKP 855
            |||.:|.....||....:..:|                           ..|.|.:|...:||..
plant   101 RPGPQRVERTTSSAARGLQSLRFLDRTVTGRERDSWRSIENRFNQFAVDGRLPKDKFGVCIGMGD 165

  Fly   856 NDMFVRKMF------------NIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRN 908
            ...|..|::            |.:||:|     .:.|.|.::   :...|.:|:|.|||||.|.:
plant   166 TLEFAAKVYEALGRRRQIKTENGIDKEQ-----LKLFWEDMI---KKDLDCRLQIFFDMCDKDGD 222

  Fly   909 GVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFV 973
            |.:.:.|:.|::.......|..:|                   .||..:|.  .|:|:|
plant   223 GKLTEEEVKEVIVLSASANRLVNL-------------------KKNAASYA--SLIMEE------ 260

  Fly   974 AIGLDCKGAKQNFLD---------------TSTNVARMTSFNIEPMQDKPRHWLLAKWDAYIT-- 1021
               ||..  :|.:::               .|..|.|.:......|..|......:|: ..:|
plant   261 ---LDPN--EQGYIEMWQLEVLLTGIVSNADSHKVVRKSQQLTRAMIPKRYRTPTSKY-VVVTAE 319

  Fly  1022 FLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLL 1086
            .:.|:.:.|:.:.|:..|.:|||:.::..::    .:.|.:|.|..:...:|:|..|....:|:|
plant   320 LMYEHWKKIWVVTLWLAVNVVLFMWKYEEFT----TSPLYNITGRCLCAAKGTAEILKLNMALIL 380

  Fly  1087 LTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIV-NFYHVSTQSHENLRC 1150
            :.:.|..:|.|:...:...||.|.:|.|||:.|......|:|||..|:: |:..:|:..:
plant   381 VPVLRRTLTFLRSTFLNHLIPFDDNINFHKLIAVAIAVISLLHTALHMLCNYPRLSSCPY----- 440

  Fly  1151 LTREVHFASDY-------KPDITFWLFQTVTGTTGVMLFIIMCIIFVFA-H-----------PTI 1196
                 :|.|||       |......|..|....|||::.|.|.|.|..| |           |..
plant   441 -----NFYSDYAGNLLGAKQPTYLGLMLTPVSVTGVLMIIFMGISFTLAMHYFRRNIVKLPIPFN 500

  Fly  1197 RKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRF----WMFFLGPGIVYTLDKIVS-LRTKYM 1256
            |...:|.||..|.|.:..|.|.:|||...:...|.:    ||:...|.::|..:::.| ::....
plant   501 RLAGFNSFWYAHHLLVIAYALLIIHGYILIIEKPWYQKTTWMYVAIPMVLYASERLFSRVQEHNH 565

  Fly  1257 ALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKA 1321
            .:.:|...:...:|:.:...:|...||.||.::.:.|......|.|.|::||||.:.:||.||:|
plant   566 RVHIIKAIVYSGNVLALYMTKPQGFKYKSGMYMFVKCPDISKFEWHPFSITSAPGDEYLSVHIRA 630

  Fly  1322 QGPWTWKLRNYF-DPC---------------------NYNP---EDQ---PKIRIEGPFGGGNQD 1358
            .|.||.:|||.| :.|                     ..||   |.|   |:|.|:||:|...|.
plant   631 LGDWTSELRNRFAETCEPHQKSKPSPNDLIRMETRARGANPHVEESQALFPRIFIKGPYGAPAQS 695

  Fly  1359 WYKFEVAVMVGGGIGVTPYASILNDL----------------------------VFGTST----- 1390
            :.||::.:::|.|||.||:.|||.|:                            |:|.|:
plant   696 YQKFDILLLIGLGIGATPFISILKDMLNNLKPGIPKTGQKYEGSVGGESLGGSSVYGGSSVNGGG 760

  Fly  1391 -----NRYSGVACK---KVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDL 1447
                 ...||...|   :.||.|:......||||..|:.|:...|.|||:|:|.::|..:...|.
plant   761 SVNGGGSVSGGGRKFPQRAYFYWVTREQASFEWFKGVMDDIAVYDKTNVIEMHNYLTSMYEAGDA 825

  Fly  1448 RTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKS 1512
            |:.::.:.:......:...|.:..:...||.||:.......:..||. .|:||||.||...|.:.
plant   826 RSALIAMVQKLQHAKNGVDIVSESRIRTHFARPNWRKVFSELSNKHE-TSRIGVFYCGSPTLVRP 889

  Fly  1513 VMSACDEV---NKTRKLPYFIHHFENF 1536
            :.|.|.|.   :.||    |..|.|||
plant   890 LKSLCQEFSLESSTR----FTFHKENF 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	15/93 (16%)
		EFh	860..921	CDD:238008	19/72 (26%)
		EF-hand_7	860..920	CDD:290234	19/71 (27%)
		EFh	895..966	CDD:238008	17/70 (24%)
		EF-hand_7	899..965	CDD:290234	15/65 (23%)
		Ferric_reduct	1084..1217	CDD:280043	44/152 (29%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	97/342 (28%)
AT3G45810	NP_190167.2	FRQ1	110..270	CDD:227455	39/199 (20%)
		NADPH_Ox	110..207	CDD:285598	16/104 (15%)
		EFh	<187..234	CDD:298682	18/54 (33%)
		EFh	214..269	CDD:298682	20/86 (23%)
		Ferric_reduct	376..522	CDD:280043	44/155 (28%)
		FAD_binding_8	566..693	CDD:285293	38/126 (30%)
		NAD_binding_6	<776..894	CDD:285298	34/118 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	41	1.000	Domainoid score	I4812
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm2409
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.710