| Sequence 1: | NP_001259968.1 | Gene: | Duox / 33477 | FlyBaseID: | FBgn0283531 | Length: | 1537 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_078781.3 | Gene: | NOX5 / 79400 | HGNCID: | 14874 | Length: | 765 | Species: | Homo sapiens |
| Alignment Length: | 809 | Identity: | 209/809 - (25%) |
|---|---|---|---|
| Similarity: | 342/809 - (42%) | Gaps: | 182/809 - (22%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 828 ASSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKT 892
Fly 893 DDKLRIIFDMCDND----------------------------RNGVIDKGELSEMMRSLVEIART 929
Fly 930 TSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVA 994
Fly 995 RMTSFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAE-HT 1058
Fly 1059 DLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTAL 1123
Fly 1124 FFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHFASDYKPDITFW--LFQTVTG---------TT 1177
Fly 1178 GVMLFIIMCIIFVFAHPTIRKKAY--NFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPG 1240
Fly 1241 IVYTLDKIVSLRTKYM-ALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSF 1304
Fly 1305 TLTSAPHE-NFLSCHIKAQGPWTWKLRNYF---DP------------------------------ 1335
Fly 1336 ---CNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVA 1397
Fly 1398 CK--------------KVYFLWICPSHKHFEWFIDVLRDVEKKDVTNV-----LEIHIFITQFFH 1443
Fly 1444 KFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSS-FLKFVQKKHSYVSKIGVFSCGPR 1507
Fly 1508 PLTKSVMSACDEVNKTRKLPYFIHHFENF 1536 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Duox | NP_001259968.1 | An_peroxidase | 70..580 | CDD:281139 | |
| dual_peroxidase_like | 72..625 | CDD:188652 | |||
| EFh | 827..882 | CDD:238008 | 19/53 (36%) | ||
| EFh | 860..921 | CDD:238008 | 21/88 (24%) | ||
| EF-hand_7 | 860..920 | CDD:290234 | 21/87 (24%) | ||
| EFh | 895..966 | CDD:238008 | 17/98 (17%) | ||
| EF-hand_7 | 899..965 | CDD:290234 | 15/93 (16%) | ||
| Ferric_reduct | 1084..1217 | CDD:280043 | 39/145 (27%) | ||
| NOX_Duox_like_FAD_NADP | 1265..1536 | CDD:99783 | 89/327 (27%) | ||
| NOX5 | NP_078781.3 | N-terminal regulatory region, interacts with the C-terminal catalytic region in a calcium-dependent manner | 1..169 | 37/139 (27%) | |
| EFh | <42..87 | CDD:238008 | 19/53 (36%) | ||
| EF-hand_7 | 62..>108 | CDD:290234 | 15/45 (33%) | ||
| EFh | 97..192 | CDD:238008 | 17/95 (18%) | ||
| EF-hand_7 | 98..190 | CDD:290234 | 16/92 (17%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 122..141 | 1/18 (6%) | |||
| Ferric_reduct | 296..402 | CDD:280043 | 34/123 (28%) | ||
| NOX_Duox_like_FAD_NADP | 448..765 | CDD:99783 | 89/332 (27%) | ||
| C-terminal catalytic region | 449..565 | 30/121 (25%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG0039 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||