Protein Alignment Duox and TPO

DIOPT Version :10

• Sequence 1: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: XP_054199614.1
• Gene: TPO / 7173
• HGNCID: 12015
• Length: 968
• Species: Homo sapiens
• Alignment Length: 756
• Identity: 194/756 - (25%)
• Similarity: 320/756 - (42%)
• Gaps: 172/756 - (22%)

  Fly     1 MSVPSAPHQRAESKNRVPRPGQKNRKLPKLRLHWPGATYGGALLLLLISYG--LELGSVHCYEKM 63
            |..|..|:....:|.| |..|..|.:          |..|.:||    |.|  .::.:..|..:
Human   149 MLPPKCPNTCLANKYR-PITGACNNR----------AGMGASLL----STGQCFQVAAPICIPR- 197

  Fly    64 YSQTEKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGAN---------RPSTRRLSR 119
                         :.:.||.||:.::.|.|..||.|.||.....|.|         .|..|.::|
Human   198 -------------SKVDHPRWGASNTALARWLPPVYEDGFSQPRGWNPGFLYNGFPLPPVREVTR 249

  Fly   120 LFMRGKDGLGSKFNR-TALLAFFGQLVANEIVMASES--------------GCPIEMHRIEIEKC 169
            ..::..:.:.:..:| :.||..:||.:.::|....:|              .|..:.....|:..
Human   250 HVIQVSNEVVTDDDRYSDLLMAWGQYIDHDIAFTPQSTSKAAFGGGSDCQMTCENQNPCFPIQLP 314

  Fly   170 DEMYDRECRGDKYIPFHRAAYDRDTGQ--------SPNAPREQINQMTAWIDGSFIYSTSEAWLN 226
            :|.  |...|...:||:|::....||.        |...||:|:|.:|:::|.|.:|.:|.|...
Human   315 EEA--RPAAGTACLPFYRSSAACGTGDQGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALER 377

  Fly   227 AMRSFHNGTLLTEKDGKLPVRNTMR---------VPLFNNPVPSVMKMLSPE---------RLFL 273
            .:|::      |..:|.|.|...:|         ||      |......:||         ..||
Human   378 QLRNW------TSAEGLLRVHARLRDSGRAYLPFVP------PRAPAACAPEPGIPGETRGPCFL 430

  Fly   274 LGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPA 338
            .||.|.::.|::.:...|:||.||.||..:|.::..||.:.:||.||..|.|..|.:.:.:|:|.
Human   431 AGDGRASEVPSLTALHTLWLREHNRLAAALKALNAHWSADAVYQEARKVVGALHQIITLRDYIPR 495

  Fly   339 FLGTS-----LPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFKETPMGYPAVR 398
            .||..     :.|||||....:|.:.::|..|||||||..|.|.:.|.|  .:|:|.| ..|.:
Human   496 ILGPEAFQQYVGPYEGYDSTANPTVSNVFSTAAFRFGHATIHPLVRRLD--ASFQEHP-DLPGL- 556

  Fly   399 LCSTWWDSSGFFADTS------VEEVLMGLASQIS--EREDPVLCSDVRDKLFGPMEFTRRDLGA 455
                 |....||:..:      ::.::.||.::.:  :.:|.::..::.::||.....:..||.:
Human   557 -----WLHQAFFSPWTLLRGGGLDPLIRGLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLAS 616

  Fly   456 LNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLF--ETQPELLDMLKEAYDNKLDDVDVYVG 518
            :|:.||||:|||.||..||..||.|.:|..|::..:.  ....::||:.|..     |::||::|
Human   617 INLQRGRDHGLPGYNEWREFCGLPRLETPADLSTAIASRSVADKILDLYKHP-----DNIDVWLG 676

  Fly   519 GMLESY---GQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTD 580
            |:.|::   .:.|..|..:|.:|.:.|||.|.||:||..  :||..:..||.|.:|..:|.::|.
Human   677 GLAENFLPRARTGPLFACLIGKQMKALRDGDWFWWENSH--VFTDAQRRELEKHSLSRVICDNTG 739

  Fly   581 VKEEEIQKDVFM---------------------WR----TGDPCPQPMQLNATELEPC------- 613
            :  ..:..|.|.                     ||    ..|.|..|..:...:...|
Human   740 L--TRVPMDAFQVGKFPEDFESCDSIPGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRV 802

  Fly   614 ---TYLEGYDYFSGSELMFIYVCVFLG--FVPILCAGAGYC 649
               :...||: ..|.|.:   .|...|  |.|.||.....|
Human   803 LVYSCRHGYE-LQGREQL---TCTQEGWDFQPPLCKDVNEC 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652	170/655 (26%)
		PTZ00184	807..965	CDD:185504
		EFh	860..921	CDD:238008
		PLN02844	<1081..>1393	CDD:215453
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783
TPO	XP_054199614.1	thyroid_peroxidase	206..773	CDD:188657	160/598 (27%)
		CCP	781..834	CDD:153056	12/56 (21%)
		EGF_CA	835..878	CDD:214542	1/5 (20%)