Protein Alignment Duox and Cybb

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_076455.1
• Gene: Cybb / 66021
• RGDID: 620574
• Length: 570
• Species: Rattus norvegicus
• Alignment Length: 584
• Identity: 155/584 - (26%)
• Similarity: 265/584 - (45%)
• Gaps: 100/584 - (17%)

  Fly  1029 NIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNL 1093
            :||.:.::..:.:.|||:.:..|....::...|.::|..:|:.|..||.|:|...|:||.:.|||
  Rat    11 SIFVILVWLGLNVFLFVKYYKVYDDEPKYNYTRKLLGSALALARAPAACLNFNCMLILLPVCRNL 75

  Fly  1094 ITKLK------EFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNF-------------YH 1139
            ::.|:      ...|::  .||.::.|||:.|......:.:||:.|:.|.             |.
  Rat    76 LSFLRGSSACCSTRIRR--QLDRNLTFHKMVAWMIALHTAIHTIAHLFNVEWCVNARVGTSDPYS 138

  Fly  1140 VSTQS---HENLRCLTREVHFASDYKPDITFWLFQTVT---GTTGVMLFIIMCIIFVFAHPTIRK 1198
            |:..:   .||...|    :||.:...:....|:..||   |.||:::.:.:.:|...:..|||:
  Rat   139 VALSNIGDKENEEYL----NFAREKIKNPEGGLYVAVTRLAGITGIVITLCLILIITSSTKTIRR 199

  Fly  1199 KAYNFFWNMHTLYIGLYLLSLIHGLARLT------------------------------------ 1227
            ..:..||..|.|::..::...|||..|:.
  Rat   200 SYFEVFWYTHHLFVIFFIGLAIHGAERIVRGQTSDSLKEHNLDVCADKIKEWGKIKECPVPKFAG 264

  Fly  1228 GPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLS 1292
            .||..|.:.:||..:|..:::|........:.:......|...|:::. :....:...||::.:.
  Rat   265 NPPMTWKWIVGPMFLYLCERLVRFWRSQQKVVITKVVTHPFKTIELQM-KKKGFRMEVGQYIFVK 328

  Fly  1293 CTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPED------QPKIRIEGP 1351
            ..|....|.|.|||||||.|:|.|.||:..|.||   ...|..|..:.::      .|||.::||
  Rat   329 RPAVSKLEWHPFTLTSAPEEDFFSIHIRIVGDWT---EGLFKACGCDKQEFQDAWKLPKIAVDGP 390

  Fly  1352 FGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWF 1416
            ||..::|.:.:||.::||.||||||.||||..:.:....|..| :..||:||.|:|.....||||
  Rat   391 FGTASEDVFSYEVVMLVGAGIGVTPSASILKSVWYKYCDNATS-LRLKKIYFYWLCRDTHAFEWF 454

  Fly  1417 IDVLR----DVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHF--QRLSKTSIFTGLKAVN 1475
            .|:|:    .:::::..|.|..:|::|.:...          ..|||  ....:..:.||||...
  Rat   455 ADLLQLLETQMQERNNANFLSYNIYLTGWDES----------QANHFAVHHDEEKDVITGLKQKT 509

  Fly  1476 HFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLP---YFIHHFENF 1536
            .:|||:..:..|.:..:|.. ::||||.|||..|.|::..  ..::.:...|   :||.:.|||
  Rat   510 LYGRPNWDNEFKTIASQHPN-TRIGVFLCGPEALAKTLSK--QSISNSESGPRGVHFIFNKENF 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	39/157 (25%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	89/285 (31%)
Cybb	NP_076455.1	Ferric_reduct	65..219	CDD:280043	39/159 (25%)
		NOX_Duox_like_FAD_NADP	297..570	CDD:99783	89/290 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710