DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and duox

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	XP_017209762.1	Gene:	duox / 565097	ZFINID:	ZDB-GENE-091117-14	Length:	1528	Species:	Danio rerio

Alignment Length:	1534	Identity:	591/1534 - (38%)
Similarity:	905/1534 - (58%)	Gaps:	100/1534 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVY-AMAGANRPSTRRLSRLFMRGKDGLGSK 131
            |.|||||||||||..|.|:.|:.|||..|..|.|||| |....:.|:.||:|...|.|:.||.|.
Zfish    30 EVQRYDGWYNNLADHDRGAADASLVRLYPAQYMDGVYLARQEPHLPNPRRISTTAMSGQSGLLSH 94

  Fly   132 FNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYDRECRGDKYIPFHRAAYDRDTGQ 196
            .||:.|...||..|.:||..:..:|||.|...|:::|.|.::.........:.|.||.:|..||:
Zfish    95 KNRSVLSVAFGYHVWSEISESRRAGCPPEFMHIKVQKDDPVFVSNSSQPVLLQFQRADWDTSTGK 159

  Fly   197 SPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPVPS 261
            |||.||.|:|.:|||||||.||.:|.:|.:|:|.|..|.|.:.....:|.|::....::::|.||
Zfish   160 SPNNPRTQVNHVTAWIDGSSIYGSSSSWSDALREFSGGRLSSSSSRDMPRRSSNGYLMWSSPDPS 224

  Fly   262 VMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIAS 326
            .......:.|:..|:...|:|...::..|::.|:||.||.::.:.||.||||:::|.||..|||:
Zfish   225 SGPDSGSQELYEFGNAWANENIFSVTEGIIWFRYHNYLASKLHKEHPSWSDEELFQHARKRVIAT 289

  Fly   327 LQNVIVYEYLPAFLGTSLPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFK--- 388
            .||:..||:|||||||.:..|.||::.:.|||...|:|||.|||.|:.|||:|:|:..|:::
Zfish   290 FQNIAFYEWLPAFLGTHVTSYPGYQKYVDPGISVEFEAAAVRFGLTLAPPGVYKRNRTCHYRSVV 354

  Fly   389 -ETPMGYPAVRLCSTWWDSSGFFADTS--VEEVLMGLASQISEREDPVLCSDVRDKLFGPMEFTR 450
             :.....|.:|||:|:|:.:.....:|  |:|::||:||||:||||.::..|:||.::||:.|:|
Zfish   355 NDDASKSPGLRLCNTFWNRNNPHLQSSLDVDELIMGMASQIAEREDNIIVEDLRDYMYGPLRFSR 419

  Fly   451 RDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDV 515
            .|..||.|.||||.|||.||..||:..:....::.||||.|.:|  :||..|.:.|:|.:..:::
Zfish   420 SDAVALTIQRGRDFGLPSYNQIREALSMAPVNSFEDINPKLKDT--KLLKELADLYENDISRLEL 482

  Fly   516 YVGGMLESYGQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTD 580
            :|||:||:...||..|:.:|.:||:|:|:||||||||::||:||.|||..:|..|..|::::.|.
Zfish   483 FVGGLLETQEGPGPVFSTIILDQFERIRNADRFWFENKQNGLFTEEEIKAIRNTTFHDVLLHVTS 547

  Fly   581 VKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYF-SGSELMFIYVCVFLGFVPILCA 644
            .::.:||:.||.|:.|||||||..:.|::|:|||......|| ..|::.|....|.|...|::..
Zfish   548 AEKGDIQRSVFFWKNGDPCPQPQPIRASDLQPCTKAFSMSYFDDSSKVGFGVTVVVLFLFPVVSY 612

  Fly   645 GAGYCVVKLQNSKRRRLKIRQEALRAPQHKGSVDKMLAREWL-HANHKRLVTVKFGPEAAIYTVD 708
            .....|.:::.::.:|  .:|:...:.:||.......|.||| |....|.||:.|..:....|.|
Zfish   613 IVASAVAQVRTARFKR--FQQKRSGSTKHKEPAHGTTASEWLGHNTAPRQVTLAFSEKKVFQTFD 675

  Fly   709 RKGEKLRTFSLKHIDVVSVEESATNHIKKKPYILLRVPSDHDLVLELESYGARRKFVKKLEDFLL 773
            ..|..|.:.||.:.|.::|..| .:|..:.  :||::|.::||||..|....|.:|:..|...|.
Zfish   676 ENGSPLSSHSLGNQDHLNVIVS-NDHQHRA--LLLKIPKEYDLVLFFEDGVQRSEFLSLLRSELE 737

  Fly   774 LHKKEMTLMEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPGERRRRSDASSDGEVMT-- 836
            ...:.:|:||.:...||..|.|||:|.|.:|.||:.|::....:         |.|..|::.:
Zfish   738 GRIQSLTVMEKSEKEMLCDAVTREQRGKIVETFFKHAFSKVLDI---------DKSDAGDLSSRT 793

  Fly   837 --VMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRII 899
              .::..|::||||:.||:|.:.:||..||.:.|||.:|.:||||||:.:|:|..|.:::|.:::
Zfish   794 REALQCELTRAEFASVLGLKSDSLFVESMFTLADKDGNGYLSFQEFLDVIVIFMTGTSEEKSKLL 858

  Fly   900 FDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLM 964
            |...|...:|.:.|.|.:.::||.::|  :.:|...|..:.|..|.|..||.:|:..:::||..:
Zfish   859 FSTHDIKGDGFLSKEEFTSLLRSFIDI--SGALSKSQADDGIAAMLQTAGLYNKDRFSWEDFHFL 921

  Fly   965 MKEYKGDFVAIGLDCKGAKQ-------NFL---DTSTNVARMT---------------------- 997
            ::::.......|::..|.|:       :|:   .:|::|..:|
Zfish   922 LRDHSAQLNIKGMEVLGKKKLGRQHKVSFIRKNSSSSSVEELTHTPEEEHGQELRQRQTKKAGQS 986

  Fly   998 -----------SFNIEPMQDKPRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHY 1051
                       .||..|:|...:.        :..|:|..|::|....:.|.::..|.:||.|:|
Zfish   987 QAKLYVRPQRERFNRNPVQQCVQQ--------FKRFIENYRRHIICTVVIYAISAGLALERCIYY 1043

  Fly  1052 SFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHK 1116
            ...|..:.:.....||:.::|||||::||.:..:|||:.|||||..:|..:.:|||.|:.|..|:
Zfish  1044 GLQAHSSGIPETSMVGVLVSRGSAAAISFLFPYMLLTVCRNLITMCRETFLNRYIPFDAAIDLHR 1108

  Fly  1117 IAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREV--HFASDYKPDITFWLFQTVTGTTGV 1179
            ..|.|||..||:|::||:||.|.........|.||..:|  :..|:.....|||.|:||.|.|||
Zfish  1109 QMAATALILSVVHSLGHLVNVYIFCISDLSILACLFPKVFSNNGSELPMKWTFWFFKTVPGITGV 1173

  Fly  1180 MLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYT 1244
            :|.:|...::|||....|:.::..||..|.||:.:|:|:::||...|...|||.::.:.||:::.
Zfish  1174 ILLLIFAFMYVFASHYFRRISFRGFWITHHLYVLIYVLTVVHGSYGLLQQPRFHIYLIPPGLLFL 1238

  Fly  1245 LDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRPHEMHSFTLTSA 1309
            |||::||..|.:.:.|:..:||||||..::|.||....|.||||||::|......|.|.||||||
Zfish  1239 LDKLISLSRKKVEIPVLKAELLPSDVTMLEFKRPQGFVYRSGQWVRIACLTLGTDEYHPFTLTSA 1303

  Fly  1310 PHENFLSCHIKAQGPWTWKLRNYFDPCNYNPEDQ------PKIRIEGPFGGGNQDWYKFEVAVMV 1368
            |||..||.||:|.||||.|||.     .|:||..      ||:.::||||.|:|:|..|||:|:|
Zfish  1304 PHEETLSLHIRAAGPWTSKLRE-----AYSPEKHQELGGLPKLYLDGPFGEGHQEWTDFEVSVLV 1363

  Fly  1369 GGGIGVTPYASILNDLVFGTSTN-RYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVL 1432
            |.||||||:||||.||||.:|.. ::.   ||||||||:..:.:.|||..|::|:||..|:.:::
Zfish  1364 GAGIGVTPFASILKDLVFKSSVKFKFH---CKKVYFLWVTRTQRQFEWLSDIIREVEDMDMQDLV 1425

  Fly  1433 EIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVS 1497
            .:||:|||...||||||||||:||.|||::...|:||||::|.|||||...:||..:|:.|..|.
Zfish  1426 SVHIYITQLPEKFDLRTTMLYVCERHFQKVWNRSLFTGLRSVTHFGRPPFLAFLSSLQEVHPEVE 1490

  Fly  1498 KIGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFENF 1536
            |:|||||||..|||:|..||.::|| |...:|:||:|||
Zfish  1491 KVGVFSCGPPGLTKNVEKACQQMNK-RDQTHFVHHYENF 1528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	218/516 (42%)
		dual_peroxidase_like	72..625	CDD:188652	236/560 (42%)
		EFh	827..882	CDD:238008	24/58 (41%)
		EFh	860..921	CDD:238008	22/60 (37%)
		EF-hand_7	860..920	CDD:290234	22/59 (37%)
		EFh	895..966	CDD:238008	19/70 (27%)
		EF-hand_7	899..965	CDD:290234	18/65 (28%)
		Ferric_reduct	1084..1217	CDD:280043	54/134 (40%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	146/277 (53%)
duox	XP_017209762.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594634
Domainoid	1	1.000	405	1.000	Domainoid score	I680
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1038	1.000	Inparanoid score	I262
OMA	1	1.010	-	-		QHG46390
OrthoDB	1	1.010	-	-		D19296at33208
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		oto38991
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R458
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.700