Protein Alignment Duox and nox1

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001095857.1
• Gene: nox1 / 555604
• ZFINID: ZDB-GENE-070404-1
• Length: 576
• Species: Danio rerio
• Alignment Length: 586
• Identity: 158/586 - (26%)
• Similarity: 263/586 - (44%)
• Gaps: 102/586 - (17%)

  Fly  1031 FYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLIT 1095
            |.:.::..:.|.|||..::.|.........|.::|..:|..|..||.|:|...|:||.:.|||::
Zfish    13 FIVVVWMAINIALFVHFYLFYDQGERFEYTRELLGSALAWARAPAAVLNFNCMLILLPVCRNLLS 77

  Fly  1096 KLKEFPIQQYI--------PLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLT 1152
            .|:    ..::        .||.::.|||:.|......:.:||:.|:.|....|.........|.
Zfish    78 LLR----GSFVCCGRTVRKQLDKNLTFHKLVAYMIALMTAVHTIAHLFNAERYSNSLEGEDGDLA 138

  Fly  1153 REVHFASDYKPDITFWL--------------FQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNF 1203
            .|:....|.....|.:|              |.::.|.|||::.:.:.::...:...||:..:..
Zfish   139 FELSLLQDSSELNTTYLNPFPSNSTTPMIFVFTSIAGLTGVVITLALILMITSSMEVIRRSYFEV 203

  Fly  1204 FWNMHTLYIGLYLLSLIHGLARLT-----------------------------------GPPRFW 1233
            ||..|.|:|..:...:.||..|:.                                   |.|:.|
Zfish   204 FWYTHHLFIVFFAGLVFHGAGRVVRGQVTTDPPHNNSFCEDQPDNWGKIPECPIPQFAGGSPQTW 268

  Fly  1234 MFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQWVRLSCTAFRP 1298
            |:.:||.|:|..::::........:......:.||.|::::..: |......||:|.|:|.|...
Zfish   269 MYVIGPMIIYICERLLRFIRYMQPVTYRKIVIRPSKVLELQLVK-PGFSMDVGQYVFLNCPAISQ 332

  Fly  1299 HEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPE--DQPK------------IRIE 1349
            .|.|.|||||||.|:|.|.||::.|.||.||....:..   ||  ..||            :.::
Zfish   333 LEWHPFTLTSAPEEDFFSVHIRSVGDWTEKLLKMVENL---PEGGQGPKYVLLWIFTITSRMGVD 394

  Fly  1350 GPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDL--VFGTSTNRYSGVACKKVYFLWICPSHKH 1412
            ||||..::|.:.:||:::||.||||||:||||..:  .|..|..:   :..|::||.|:|.....
Zfish   395 GPFGTASEDVFHYEVSMLVGAGIGVTPFASILKSIWYKFKDSDPK---LRTKRIYFYWLCRETHA 456

  Fly  1413 FEWFIDVL----RDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKA 1473
            ||||.|:|    |::|::.:.:.|...:::|.:.........:      ||.:  .|.|.||||.
Zfish   457 FEWFADLLQVLEREMEERGMRDFLTYKLYLTGWDQSHADHAMV------HFDK--DTDIITGLKQ 513

  Fly  1474 VNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSAC---DEVNKTRKLPYFIHHFEN 1535
            ..|:|||:.....:.|::::. .|.:|.|.|||:.|.|.:...|   .:|:..|...||  :.||
Zfish   514 KTHYGRPNWDKEFEQVRQENP-SSVVGTFLCGPQALAKDLEKKCVKYSDVDPRRTKFYF--NKEN 575

  Fly  1536 F 1536
            |
Zfish   576 F 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	35/154 (23%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	96/293 (33%)
nox1	NP_001095857.1	Ferric_reduct	66..218	CDD:280043	35/155 (23%)
		NOX_Duox_like_FAD_NADP	298..576	CDD:99783	96/295 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.710