Protein Alignment Duox and Tpo

DIOPT Version :10

• Sequence 1: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_062226.2
• Gene: Tpo / 54314
• RGDID: 3900
• Length: 914
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 176/691 - (25%)
• Similarity: 299/691 - (43%)
• Gaps: 141/691 - (20%)

  Fly    74 GWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGAN---------RPSTRRLSR-LFMRGKDGL 128
            |..||..||.||:.::.|.|..||.|.||.....|.|         .|..|.::| |.....:.:
  Rat   150 GVCNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPNFLYHGFPLPPVREVTRHLIQVSNEAV 214

  Fly   129 GSKFNRTALLAFFGQLVANEIVMASES--------GCPIEMHRIEIEKCD--------EMYDREC 177
            ......:..|..:||.:.::|.:..:|        |...::      .|:        ::.....
  Rat   215 TEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQL------TCENQNPCFPIQLPSNSS 273

  Fly   178 RGDKYIPFHRAAYDRDTGQ--------SPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNG 234
            |....:||:|::....||.        |...||:|:|.:|:::|.|.:|.:|......:|::.:.
  Rat   274 RTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTSFLDASTVYGSSPGVEKQLRNWSSS 338

  Fly   235 TLLTEKDGKLPVRNTMRVPLFNNPVPSVMKMLSPE---------RLFLLGDPRTNQNPAILSFAI 290
            .      |.|.| ||:.:......:|......:||         ..||.||.|.::.||:.:...
  Rat   339 A------GLLRV-NTLHLDSGRAYLPFASAACAPEPGAPHANRTPCFLAGDGRASEVPALAAVHT 396

  Fly   291 LFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTS-----LPPYEGY 350
            |:||.||.||...|.::..||....||.||..|.|..|.:.:.:|:|..||..     :.|||||
  Rat   397 LWLREHNRLATAFKAINTHWSANTAYQEARKVVGALHQIITMRDYIPKILGPDAFRQYVGPYEGY 461

  Fly   351 KQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFKE-TPMGYPAVRLCSTWWDSSGFFADTS 414
            ...::|.:.::|..|||||||..:.|.:.|.:  .:|:: |.:  |.::|...::.......:..
  Rat   462 NPTVNPTVSNVFSTAAFRFGHATVHPLVRRLN--TDFQDHTEL--PRLQLHDVFFRPWRLIQEGG 522

  Fly   415 VEEVLMGLAS-----QISEREDPVLCSDVRDKLFGPMEFTRRDLGALNIMRGRDNGLPDYNTARE 474
            ::.::.||.:     |:.|:   ::..::.::||........||.:||:.||||:|||.||..||
  Rat   523 LDPIVRGLLARPAKLQVQEQ---LMNEELTERLFVLSNVGTLDLASLNLQRGRDHGLPGYNEWRE 584

  Fly   475 SYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESY---GQPGEFFTAVIK 536
            ..||.|.:|..::|..:  ....:::.:.|.|.: .|::||::||:.|.:   .:.|..|..:|.
  Rat   585 FCGLSRLETPAELNKAI--ANRSMVNKIMELYKH-ADNIDVWLGGLAEKFLPGARTGPLFACIIG 646

  Fly   537 EQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTDVKE------------------ 583
            :|.:.|||.||||:||..  :||..:..||.|.:|..:|.::|.:..
  Rat   647 KQMKALRDGDRFWWENSH--VFTDAQRQELEKHSLPRVICDNTGLTRVPVDAFRIGKFPQDFESC 709

  Fly   584 EEI-QKDVFMWR----TGDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGF----- 638
            ||| ..|:.:||    ..|.|..|.:::......|.        ...:|:.:|.| |.|:
  Rat   710 EEIPSMDLRLWRETFPQDDKCVFPEKVDNGNFVHCE--------ESGKLVLVYSC-FHGYKLQGQ 765

  Fly   639 ------------VPILCAGAGYCV----------VKLQNSK 657
                        .|.:|.....|.          .|.:|:|
  Rat   766 EQVTCTQNGWDSEPPVCKDVNECADLTHPPCHSSAKCKNTK 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652	165/630 (26%)
		PTZ00184	807..965	CDD:185504
		EFh	860..921	CDD:238008
		PLN02844	<1081..>1393	CDD:215453
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783
Tpo	NP_062226.2	thyroid_peroxidase	161..722	CDD:188657	154/585 (26%)
		CCP	730..783	CDD:153056	9/61 (15%)
		EGF_CA	784..813	CDD:429571	4/23 (17%)
		FXa_inhibition	<802..826	CDD:464251	2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..907