DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and DUOX1

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_059130.2	Gene:	DUOX1 / 53905	HGNCID:	3062	Length:	1551	Species:	Homo sapiens

Alignment Length:	1549	Identity:	618/1549 - (39%)
Similarity:	889/1549 - (57%)	Gaps:	105/1549 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAG-ANRPSTRRLSRLFMRGKDGLGSK 131
            |.||:|||||||....|||..|.|.|..|.||:||||...| .:.|:.|.||....||..||.|.
Human    28 EVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLSNTISRGPAGLASL 92

  Fly   132 FNRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYDRECRGDKYIPFHRAAYDRDTGQ 196
            .|||.|..|||..|.:::|.....|||.|...|.|...|.|:|.:.|||..:||.|:.:|.:||:
Human    93 RNRTVLGVFFGYHVLSDLVSVETPGCPAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGR 157

  Fly   197 SPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPVPS 261
            ||:.||:..||:|.|:|||.||.:|.:|.:|:|||..|.|.:..|...|..:...:.::..|.|:
Human   158 SPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDPA 222

  Fly   262 VMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIAS 326
            ..:. .|..|:..|..|.|:.|.:.:..:|:.|:||..|||:.|.||||.||:::|.||..|||:
Human   223 TGQN-GPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIAT 286

  Fly   327 LQNVIVYEYLPAFLGTSLPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPGIYRRDGQCNFK--- 388
            .||:.|||:||:||..:||.|.||:..:.|.|...|.||:.:|..||:|||:|.|:..|:|:
Human   287 YQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVI 351

  Fly   389 -ETPMGYPAVRLCSTWW--DSSGFFADTSVEEVLMGLASQISEREDPVLCSDVRDKLFGPMEFTR 450
             .......|:|:|:::|  :.....:...|:.:|:|:||||:||||.||..||||...||::|:|
Human   352 NRNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSR 416

  Fly   451 RDLGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDV 515
            .|..|..:.||||.|||.|..||.:.||.....|.||||.|..:...:|:.....|:..|..:::
Human   417 TDHLASCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAALYNQDLSWLEL 481

  Fly   516 YVGGMLESYGQPGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTD 580
            ..||:|||:..||..|:.::.|||.||||.||:||||.|||:|:.:||.|:|..||.|::|...:
Human   482 LPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVIN 546

  Fly   581 VKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGFVPILCAG 645
            :....:|.:||:|..|||||||.||:...|..|......|||.||...|......|...|::...
Human   547 IDPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLL 611

  Fly   646 AGYCVVKL--QNSKRRRLKIRQEALRAPQHKGSVDKMLAREWLHANHK---RLVTVKFGPEAAIY 705
            :.:.|.:|  :|.||.:.:.||..:    .:..|..|.|.||  ..||   |.|.|...| ..|.
Human   612 SAWIVARLRMRNFKRLQGQDRQSIV----SEKLVGGMEALEW--QGHKEPCRPVLVYLQP-GQIR 669

  Fly   706 TVDRKGEKLRTFSLKHIDVVSVEESATNHIKKKPYILLRVPSDHDLVLELESYGARRKFVKKLED 770
            .||.:...|||..|:....|:...|:.   :.:..:||::|.::||||.......|:..|:.|..
Human   670 VVDGRLTVLRTIQLQPPQKVNFVLSSN---RGRRTLLLKIPKEYDLVLLFNLEEERQALVENLRG 731

  Fly   771 FLLLHKKEMTL----MEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPGERRRRSDA--- 828
            .|    ||..|    .|:....::..|.|||:|:..||.|||..::....:      .::||
Human   732 AL----KESGLSIQEWELREQELMRAAVTREQRRHLLETFFRHLFSQVLDI------NQADAGTL 786

  Fly   829 --SSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGK 891
              .|..:|...:...||:||||.:||:||.||||..||::.|||.:|.:||:|||:.:|:|.:|.
Human   787 PLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGS 851

  Fly   892 TDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHL 956
            .::|.|::|.|.|.|.||:|.|.|...|:||.:||: ...|...|:.|:::.||::.|.:.|..|
Human   852 PEEKSRLMFRMYDFDGNGLISKDEFIRMLRSFIEIS-NNCLSKAQLAEVVESMFRESGFQDKEEL 915

  Fly   957 TYQDFKLMMKEYKGDFVAIGLDCKGAK----------------QNFLDTSTNV-ARMTSFNIE-- 1002
            |::||..|::::..:.....|..||.:                |:.:..|..| ||.:..:||
Human   916 TWEDFHFMLRDHNSELRFTQLCVKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSDIETE 980

  Fly  1003 --------PMQDKPRHWLLAKWDAYIT-----------------------------FLEENRQNI 1030
                    ||...|...:..::...:|                             |:|..|::|
Human   981 LTPQRLQCPMDTDPPQEIRRRFGKKVTSFQPLLFTEAHREKFQRSCLHQTVQQFKRFIENYRRHI 1045

  Fly  1031 FYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLIT 1095
            ..:.:||.:...||:||..:|:|.|.||.:.....|||.::||:|||:||.:|.:||||.|||||
Human  1046 GCVAVFYAIAGGLFLERAYYYAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLIT 1110

  Fly  1096 KLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVHF--A 1158
            .|:|..:.:|:|.|:.:.||::.|.||:..:|||:|||:||.|..|......|.||...:..  .
Human  1111 FLRETFLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSCLFPGLFHDDG 1175

  Fly  1159 SDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGL 1223
            |:......:|.||||.|.|||:|.:|:.|::|||....|::::..||..|.|||.||:|.:|||.
Human  1176 SELPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRRRSFRGFWLTHHLYILLYVLLIIHGS 1240

  Fly  1224 ARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSGQW 1288
            ..|...|||.:|||.|.|:|..||:|||..|.:.:.|:..:||||.|..::|.||...:|.||||
Human  1241 FALIQLPRFHIFFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQW 1305

  Fly  1289 VRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRN-YFDPCNYNPEDQPKIRIEGPF 1352
            ||::|.|....|.|.|||||||||:.||.||:|.||||.:||. |..|........||:.::|||
Human  1306 VRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTGDRCARYPKLYLDGPF 1370

  Fly  1353 GGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFI 1417
            |.|:|:|:||||:|:|||||||||:||||.||||.:|.:  ..|.|||:||:|:..:.:.|||..
Human  1371 GEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVS--CQVFCKKIYFIWVTRTQRQFEWLA 1433

  Fly  1418 DVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDM 1482
            |::|:||:.|..:::.:||:|||...|||||||||||||.|||::...|:||||:::.|||||..
Human  1434 DIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPF 1498

  Fly  1483 SSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTRKLPYFIHHFENF 1536
            ..|...:|:.|..|.|||||||||..:||:|..||..:|:..: .:|.||:|||
Human  1499 EPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLINRQDR-THFSHHYENF 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	220/516 (43%)
		dual_peroxidase_like	72..625	CDD:188652	236/559 (42%)
		EFh	827..882	CDD:238008	28/59 (47%)
		EFh	860..921	CDD:238008	27/60 (45%)
		EF-hand_7	860..920	CDD:290234	26/59 (44%)
		EFh	895..966	CDD:238008	28/70 (40%)
		EF-hand_7	899..965	CDD:290234	25/65 (38%)
		Ferric_reduct	1084..1217	CDD:280043	57/134 (43%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	142/271 (52%)
DUOX1	NP_059130.2	Peroxidase-like, mediates peroxidase activity	26..593		241/565 (43%)
		An_peroxidase	30..544	CDD:281139	220/514 (43%)
		dual_peroxidase_like	32..591	CDD:188652	236/559 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..172		10/21 (48%)
		EFh	820..881	CDD:238008	27/60 (45%)
		EF-hand_7	820..880	CDD:290234	26/59 (44%)
		EF-hand_7	857..921	CDD:290234	25/64 (39%)
		EFh	857..915	CDD:238008	22/58 (38%)
		Interaction with TXNDC11. /evidence=ECO:0000250	956..1248		99/291 (34%)
		Ferric_reduct	1091..1226	CDD:280043	56/134 (42%)
		NOX_Duox_like_FAD_NADP	1277..1551	CDD:99783	143/276 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	428	1.000	Domainoid score	I599
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1087	1.000	Inparanoid score	I242
Isobase	1	0.950	-	0	Normalized mean entropy	S4061
OMA	1	1.010	-	-		QHG46390
OrthoDB	1	1.010	-	-		D19296at33208
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm41000
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R458
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.720