Protein Alignment Duox and NOX4

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_001278856.1
• Gene: NOX4 / 50507
• HGNCID: 7891
• Length: 599
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 155/606 - (25%)
• Similarity: 250/606 - (41%)
• Gaps: 151/606 - (24%)

  Fly  1034 FLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLK 1098
            |::..:.::||.:.|:.|:...|:..|..::|:|:.::|.||:.|:...||:||.|.|.|:..|:
Human    41 FIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLR 105

  Fly  1099 EFPIQQYIP-------LDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREVH 1156
            .   .|.:|       ||....||.....|...||.:|...|:||..:.|....|:.    .|::
Human   106 G---SQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDF----VELN 163

  Fly  1157 FASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIH 1221
            .|.....|....||.||.|.|||.:.:::.::...:...||...|:.||..|.|:...|:|..:|
Human   164 AARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLH 228

  Fly  1222 ---GLARL-----TGP------------------------------------------------- 1229
               ||.:.     |.|
Human   229 VSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICME 293

  Fly  1230 -PRF-------WMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLSG 1286
             |||       |::..||..:|..:::.........:.:|.....||||::|:..: .|.|...|
Human   294 EPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVISHPSDVMEIRMVK-ENFKARPG 357

  Fly  1287 QWVRLSCTAFRPHEMHSFTLTSAPHEN--FLSCHIKAQGPWTWKLRNYFDPCNYNPEDQ------ 1343
            |::.|.|.:....|.|.||||..|.|.  ....|:|..|.||.:.|:...|    |..|
Human   358 QYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLP----PSSQDSEILP 418

  Fly  1344 -------PKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKV 1401
                   ||:.|:||||...::...:||::.|.|||||||:|||||.|:     :.:.....:::
Human   419 FIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLL-----DDWKPYKLRRL 478

  Fly  1402 YFLWICPSHKHFEWFIDVLRDVEKK-------DVTNVLEIHIFITQ-------FFHKFDLRTTML 1452
            ||:|:|...:.|.||.|:|..:..|       |..|   |.::::|       ...|:....:.|
Human   479 YFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVN---IQLYLSQTDGIQKIIGEKYHALNSRL 540

  Fly  1453 YICENHFQRLSKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSAC 1517
            :|                       |||........: .|::....:|||.|||..|:|::....
Human   541 FI-----------------------GRPRWKLLFDEI-AKYNRGKTVGVFCCGPNSLSKTLHKLS 581

  Fly  1518 DEVNK--TRKLPYFIHHFENF 1536
            ::.|.  ||    |.::.|:|
Human   582 NQNNSYGTR----FEYNKESF 598

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	41/139 (29%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	85/301 (28%)
NOX4	NP_001278856.1	Ferric_reduct	90..225	CDD:280043	42/141 (30%)
		NOX_Duox_like_FAD_NADP	332..598	CDD:99783	86/306 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810