Protein Alignment Duox and Nox4

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: XP_006508075.1
• Gene: Nox4 / 50490
• MGIID: 1354184
• Length: 617
• Species: Mus musculus
• Alignment Length: 629
• Identity: 148/629 - (23%)
• Similarity: 246/629 - (39%)
• Gaps: 184/629 - (29%)

  Fly  1033 LFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKL 1097
            |.::..:.::||.:.|:.|:...|:..:..::|:|:.::|.||:.|:...||:||.|.|.::..|
Mouse    19 LLIWLSLNVLLFWKTFLLYNQGPEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYL 83

  Fly  1098 KEFPIQQYIP-------LDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVSTQSHENLRCLTREV 1155
            :.   .|.:|       ||.....|.....|...||.:|...|:||..:.|....|:.    .|:
Mouse    84 RG---SQKVPSRRTRRLLDKSKTLHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDF----LEL 141

  Fly  1156 HFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLI 1220
            :.|.....|....||.|:.|.|||.:.:::.::...:...||...|:.||..|.|:...|:|.|:
Mouse   142 NAARYQNEDPRKLLFTTIPGLTGVCMVVVLFLMVTASTYAIRVSNYDIFWYTHNLFFVFYMLLLL 206

  Fly  1221 H---GLARL-----TGP------------------------------------------------ 1229
            |   ||.:.     |.|
Mouse   207 HVSGGLLKYQTNVDTHPPGCISLNQTSSQNMSIPDYVSEHFHGSLPRGFSKLEDRYQKTLVKICL 271

  Fly  1230 ---------PRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLPSDVIKIKFYRPPNLKYLS 1285
                     |:.|::..||..:|..:::.........:.:|.....||||::::..: .|.|...
Mouse   272 EEPKFQAHFPQTWIWISGPLCLYCAERLYRCIRSNKPVTIISVINHPSDVMELRMIK-ENFKARP 335

  Fly  1286 GQWVRLSCTAFRPHEMHSFTLT------------------------SAPHEN-------FLSC-- 1317
            ||::.|.|.:....|.|.||||                        :|.||:       ||.|
Mouse   336 GQYIILHCPSVSALENHPFTLTMLCQKRWQPWHSRVWIYSFFVCSDAACHEDTSKMNHAFLLCPT 400

  Fly  1318 --------HIKAQGPWTWKLRNYFDPCNYNPEDQ-------------PKIRIEGPFGGGNQDWYK 1361
                    |.|..|.||.:.|:...|    |..|             ||:.|:||||...::...
Mouse   401 ETKATFGVHFKVVGDWTERFRDLLLP----PSSQDSEILPFIHSRNYPKLYIDGPFGSPFEESLN 461

  Fly  1362 FEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKK 1426
            :||::.|.|||||||:|||||.|:     :.:.....:::||:|:|...:.|:||.|:|..:..|
Mouse   462 YEVSLCVAGGIGVTPFASILNTLL-----DDWKPYKLRRLYFIWVCRDIQSFQWFADLLCVLHNK 521

  Fly  1427 -------DVTNVLEIHIFITQ-------FFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHF 1477
                   |..|   |.::::|       ...|:....:.|:|
Mouse   522 FWQENRPDFVN---IQLYLSQTDGIQKIIGEKYHTLNSRLFI----------------------- 560

  Fly  1478 GRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVN 1521
            |||........:.|.:. ...:|||.|||..::|::.|..:..|
Mouse   561 GRPRWKLLFDEIAKCNR-GKTVGVFCCGPSSISKTLHSLSNRNN 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	38/139 (27%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	84/325 (26%)
Nox4	XP_006508075.1	Ferric_reduct	69..204	CDD:366815	39/141 (28%)
		NOX_Duox_like_FAD_NADP	311..616	CDD:99783	85/330 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810