DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and Nox3

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_001004216.1	Gene:	Nox3 / 292279	RGDID:	1303190	Length:	568	Species:	Rattus norvegicus

Alignment Length:	600	Identity:	166/600 - (27%)
Similarity:	275/600 - (45%)	Gaps:	104/600 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1008 PRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITR 1072
            |..|:|.:..:::..|           |:..:.|.||::.|..|:........|.|:|..:|..|
  Rat     2 PTCWILNESVSFVVAL-----------LWLAINIYLFIDTFCWYAEEESFFYTRVILGSALAWAR 55

  Fly  1073 GSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIP----LDSHIQFHKIAACTALFFSVLHTVGH 1133
            .||..|:|...|:||.:|||.::.::...:....|    ||.:::|||:.|......||:|.|.|
  Rat    56 ASAVCLNFNCMLILLPVSRNFVSLVRGTSVCCRGPWRRQLDKNLKFHKLVAYGIAVNSVIHIVAH 120

  Fly  1134 IVNF--YHV-STQSHENLRCLTREVHFA---SDYKPDITFW------LFQTVTGTTGVMLFIIMC 1186
            :.|.  ||: ..:..|.|.....::..|   |...|..|.:      |..||:|.||:::.:.:.
  Rat   121 LFNLERYHLGQAKDAEGLLAALSKLGNAPNESYLNPVRTLYTGTTTQLLMTVSGITGLVISLALI 185

  Fly  1187 IIFVFAHPTIRKKAYNFFWNMHTLYIGLYLLSLIHGLARL------------------------- 1226
            :|...:...||:.:|..||..|.::|.|::...|||..|:
  Rat   186 LIMTSSTEFIRQSSYELFWYTHHIFIFLFISLAIHGGGRIIRGQTPESLRLHNVTFCRDHFDEWQ 250

  Fly  1227 ----------TG-PPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLL--PSDVIKIKFYRP 1278
                      :| .|..|.:.|||.::|..:.|:.....:.  :|:.|.::  ||.|:::.. :.
  Rat   251 EAASCPVPQFSGKEPSAWKWTLGPVVLYACEIIIRFWRSHQ--EVVITKVVSHPSAVLELHM-KK 312

  Fly  1279 PNLKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTWKLRNYFDPCNYNPED- 1342
            .:.|...||::.:.|.:..|.|.|.|||||||.|:|.|.||:|.|.||..|...|......|.:
  Rat   313 RDFKMAPGQYIFIQCPSISPLEWHPFTLTSAPQEDFFSVHIRASGDWTEALLKAFGAEGQAPSEL 377

  Fly  1343 --QPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACKKVYFLW 1405
              .|::.::|||||...|.:.:.|:|.:..||||||:||:|..:.:....:: |.....||||.|
  Rat   378 CSMPRLAVDGPFGGSLADVFHYPVSVCIATGIGVTPFASLLKSVWYKCCESQ-SLPGLSKVYFYW 441

  Fly  1406 ICPSHKHFEWFIDVLRDVE----KKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQRL---- 1462
            ||.....||||.|:|..:|    ::...::|..||::|.:               :.:|.:
  Rat   442 ICRDAAAFEWFADLLLSLETQMSEQGKAHLLSYHIYLTGW---------------DEYQAIHIAL 491

  Fly  1463 ---SKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVNKTR 1524
               ....:.||||....:|||:.:...|.:...|. .|.||||.|||:.::|::...|...:.:.
  Rat   492 HWDESLDVITGLKQKTFYGRPNWNEEFKQIAYNHP-SSSIGVFFCGPKAMSKTLQKMCRLYSSSD 555

  Fly  1525 KLPYFIHHF---ENF 1536
              |..:|.:   |||
  Rat   556 --PRGVHFYYNKENF 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	42/148 (28%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	89/289 (31%)
Nox3	NP_001004216.1	Ferric_reduct	66..217	CDD:280043	42/150 (28%)
Nox3	NP_001004216.1	NOX_Duox_like_FAD_NADP	295..568	CDD:99783	90/292 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.710