Protein Alignment Duox and frp2

DIOPT Version :9

• Sequence 1: NP_001259968.1
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_595271.1
• Gene: frp2 / 2541227
• PomBaseID: SPBC947.05c
• Length: 564
• Species: Schizosaccharomyces pombe
• Alignment Length: 592
• Identity: 122/592 - (20%)
• Similarity: 221/592 - (37%)
• Gaps: 158/592 - (26%)

  Fly  1009 RHWLLAKWDAYITFLEENRQNIFYLF--LFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAIT 1071
            |||.:        ||..::..:..:.  |..:|||          .|..:.|. ..|......:|
pombe    63 RHWFI--------FLATHKAQMTLILSPLVMLVTI----------PFTGKETK-NSIASYDWNLT 108

  Fly  1072 RGSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVN 1136
             |.||.|.: .|..|..:|.....|...|.:..:...:.....|:..:..|:..||||.    :.
pombe   109 -GVAARLGY-LSCGLFFVSYFFSLKNNPFCLMLFSSHEKMNYLHRWLSVYAVLISVLHG----IL 167

  Fly  1137 FYHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAY 1201
            |...|.||                |||     |........|..:.:::.::.|.:.|::|:|.:
pombe   168 FMIFSAQS----------------YKP-----LLYDKISIYGYFITVVLFLMTVASLPSVRRKFF 211

  Fly  1202 NFFWNMH---TLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDT 1263
            .:|:.:|   ::.| ::|:.|.|        ||..::.....|:|..|:...|............
pombe   212 EWFFVLHHTCSVLI-IFLIWLHH--------PRTIVYMKACIIIYAFDRGCRLFRSIWNRSNFRI 267

  Fly  1264 DLLPSDVIKIKFYRPPN----LKYLSGQWVRLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGP 1324
            .||..|:|.:...:|..    |.:.:|..|.::..:....::|.|||.|||.::|:...:.....
pombe   268 YLLNEDMIYMVGRKPKRSFFALPWAAGSHVYINIPSLSYWQVHPFTLASAPFDDFIELFVAVHSG 332

  Fly  1325 WTWKLRN--YFDP---------------------------------------CNYNPED---QPK 1345
            :|.:|.|  |..|                                       ..|.|||   :..
pombe   333 FTERLANRLYSMPHEYPNFSLAPGTPESLSNTYRELNSFKSYAVEIENTAQGHTYEPEDLYLETT 397

  Fly  1346 IRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNRYSGVACK--KVYFLWICP 1408
            :.::||:|..:..:.::...:::.||:|.:....||.||:.         ..|.  .:.|:|.|.
pombe   398 VFMDGPYGTTSNVFKEYSYVLLIAGGVGFSYTLPILRDLIL---------KECNVTSITFIWSCR 453

  Fly  1409 SHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICENHFQ---RLSKTSIFTG 1470
            |       :.:|: |..|.:.::|          |:.::|..::    |||.   ...::|.|:.
pombe   454 S-------LSLLK-VASKSLNSLL----------HQSNVRLKII----NHFTGSISCKESSEFSN 496

  Fly  1471 LKAVN---HF--GRPDMSSFLKFVQKKHSYV--SKIGVFSCGPRPLTKSVMSACDEVNKTRKLPY 1528
            ....|   .|  .|||:.   .::||...||  ....:.:||.:...|.:.::   |||:.....
pombe   497 QTTENSEMEFFDDRPDLD---MYIQKFFDYVGYQTAALAACGSQSFLKRIKNS---VNKSISSTT 555

  Fly  1529 FIH-HFE 1534
            .|: |:|
pombe   556 DIYQHYE 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008
		EFh	860..921	CDD:238008
		EF-hand_7	860..920	CDD:290234
		EFh	895..966	CDD:238008
		EF-hand_7	899..965	CDD:290234
		Ferric_reduct	1084..1217	CDD:280043	26/135 (19%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	69/331 (21%)
frp2	NP_595271.1	Ferric_reduct	117..228	CDD:280043	27/136 (20%)
		NOX_Duox_like_FAD_NADP	271..488	CDD:99783	47/247 (19%)
		NAD_binding_6	414..547	CDD:285298	35/169 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R458
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740