Protein Alignment Duox and K10B4.1

DIOPT Version :10

• Sequence 1: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Sequence 2: NP_493669.2
• Gene: K10B4.1 / 187249
• WormBaseID: WBGene00019613
• Length: 1294
• Species: Caenorhabditis elegans
• Alignment Length: 623
• Identity: 165/623 - (26%)
• Similarity: 276/623 - (44%)
• Gaps: 117/623 - (18%)

  Fly    72 YDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGV-----YAMAGANRPSTRRLSRLFMRGKDGLGSK 131
            |.||.|||..|...:....|.|..||:|.||:     ..:.|:..||.|.:|.:....|.....|
 Worm   665 YTGWCNNLETPSLANTFRELRRLLPPAYEDGIDLPRSKTITGSRLPSPRVISNMVHHAKKIEHVK 729

  Fly   132 FNRTALLAFFGQLVANEIVMASESGCPIEMH----RIEIEKCD--EMYDREC-------RGDKYI 183
            ::.  .:..|||.:.::|..:     |::.:    .:...:||  ......|       ....:.
 Worm   730 YSH--FVMEFGQFIDHDITHS-----PVDQNSDGTALNCSRCDSGRFVSPSCFPIPVPVNDVHFE 787

  Fly   184 PFHRAAYDRD-TGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVR 247
            ||...::.|. ..|.....|.|:||::|::|||.:|.:::...:.:|:|        :|||:...
 Worm   788 PFSCLSFVRSLPAQKTLGYRNQMNQVSAYLDGSVMYGSTKCEGDRLRTF--------QDGKMKTT 844

  Fly   248 NTMRVPLFNNPVPSVMK-------MLSPER-LFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIK 304
            .|.|.|.......|...       :.:|:. .|:.||.|.:|...:::...:|.|.|..:...:|
 Worm   845 QTSRAPRHYGITLSQSDESEQDGCVSAPDAPCFIAGDDRNSQQTLLIAVHSVFHREHERITTTLK 909

  Fly   305 RVHPDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTSL-------PPYEGY---KQDIHPGIG 359
            .::|:|.||.|||..|..:.|...:::..||||..:|..|       |..:||   .::....|.
 Worm   910 EINPNWDDEKIYQETRKLISAEFAHIVYNEYLPIIIGQKLIDDYDLRPRQDGYYDGYENCDASIL 974

  Fly   360 HIFQAAAFRFGHTMIPPGIYRRDGQCNFKETPMGY----PA---VRLCSTWWDSSGFFADTSVEE 417
            ..|..|||||||:.:.            :.|||..    ||   |.|.|.:.:.|..:.:.:||:
 Worm   975 QPFATAAFRFGHSTVT------------RFTPMQETVHDPATCVVDLASDFLNMSKIYDNEAVEQ 1027

  Fly   418 VLMGLASQISEREDPVLCSDVRDKLFGP--MEFTRRDLGALNIMRGRDNGLPDYNTARESYGLKR 480
            :|.|:..:.....|..:...:|:.||..  ...|..||.::||.||||:|:|.||..|...||.|
 Worm  1028 ILGGMHGKHQMMTDRFVDDAIRNFLFSDRGRRGTGLDLISINIQRGRDHGIPPYNHYRSFCGLSR 1092

  Fly   481 ----HKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYVGGMLESY---GQPGEFFTAVIKEQ 538
                :..::|||       .:.|..:.:.|::. ||:|::.|.:.|..   |..|.....:|.||
 Worm  1093 LTSFYSIFSDIN-------QDGLTAIGKVYESP-DDIDLFTGIVSEKTIPGGIVGPTAACIIAEQ 1149

  Fly   539 FQRLRDADRFWFEN-ERNGIFTPEEIAELRKITLWDIIVNSTDVKEEEIQKDVF----------- 591
            |:||:..|||::|| |.:..|:..::.|:||.::..:|..:|  |..:|.||||
 Worm  1150 FRRLKKCDRFYYENGEDHSKFSASQLKEVRKTSMSALICANT--KVPKISKDVFSVPDPFSNPLI 1212

  Fly   592 -----------MWRTGDPC---PQPMQLNAT-ELEPCT 614
                       .||....|   .:.:||::: ::..||
 Worm  1213 NCDLYPKLDLSKWRDAKDCIYKGKTIQLHSSQDISACT 1250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652	165/623 (26%)
		PTZ00184	807..965	CDD:185504
		EFh	860..921	CDD:238008
		PLN02844	<1081..>1393	CDD:215453
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783
K10B4.1	NP_493669.2	An_peroxidase	93..520	CDD:460804
		An_peroxidase	662..1201	CDD:460804	156/572 (27%)