DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and bli-3

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	NP_490686.3	Gene:	bli-3 / 171608	WormBaseID:	WBGene00000253	Length:	1497	Species:	Caenorhabditis elegans

Alignment Length:	1510	Identity:	649/1510 - (42%)
Similarity:	925/1510 - (61%)	Gaps:	80/1510 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EKQRYDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGANRPSTRRLSRLFMRGKDGLGSKF 132
            |.|||||||||||:.:|||..|.|.|.|...||||||:: ..:.||.|.||.:..:|:.|:.:..
Worm    27 EFQRYDGWYNNLANSEWGSAGSRLHRDARSYYSDGVYSV-NNSLPSARELSDILFKGESGIPNTR 90

  Fly   133 NRTALLAFFGQLVANEIVMASESGCPIEMHRIEIEKCDEMYDRECRGDKYIPFHRAAYDRDTGQS 197
            ..|.|||||.|:||.||:.::...||:|..:|::..||.::|:||.|...|||.||.||:.||..
Worm    91 GCTTLLAFFSQVVAYEIMQSNGVSCPLETLKIQVPLCDNVFDKECEGKTEIPFTRAKYDKATGNG 155

  Fly   198 PNAPREQINQMTAWIDGSFIYSTSEAWLNAMRSFHNGTLLTEKDGKLPVRNTMRVPLFNNPV-PS 261
            .|:||||||:.|:||||||||.|::.|::::|||..|.|.....|..|:.|. .:|| |||. |.
Worm   156 LNSPREQINERTSWIDGSFIYGTTQPWVSSLRSFKQGRLAEGVPGYPPLNNP-HIPL-NNPAPPQ 218

  Fly   262 VMKMLSPERLFLLGDPRTNQNPAILSFAILFLRWHNTLAQRIKRVHPDWSDEDIYQRARHTVIAS 326
            |.:::||:|||:|||.|.|:||.:|||.::..||||..|.:|.|.||||:||.|:|.||..||||
Worm   219 VHRLMSPDRLFMLGDSRVNENPGLLSFGLILFRWHNYNANQIHREHPDWTDEQIFQAARRLVIAS 283

  Fly   327 LQNVIVYEYLPAFLG--TSLPPYEGYKQDIHPGIGHIFQAAAFRFGHTMIPPG--IYRRDGQCNF 387
            :|.:|.|:::|..||  ..|..|..|...:.|||.|.|.||||||.|:::||.  :.:|..:|.|
Worm   284 MQKIIAYDFVPGLLGEDVRLSNYTKYMPHVPPGISHAFGAAAFRFPHSIVPPAMLLRKRGNKCEF 348

  Fly   388 KETPMGYPAVRLCSTWWDSSGFFADTSVEEVLMGLASQISEREDPVLCSDVRDKLFGPMEFTRRD 452
            :....||||:|||..||::.....:.||:|:::|:||||:||:|.::..|:||.:||||.|:|.|
Worm   349 RTEVGGYPALRLCQNWWNAQDIVKEYSVDEIILGMASQIAERDDNIVVEDLRDYIFGPMHFSRLD 413

  Fly   453 LGALNIMRGRDNGLPDYNTARESYGLKRHKTWTDINPPLFETQPELLDMLKEAYDNKLDDVDVYV 517
            :.|.:||||||||:|.||..|.::|| ..|||..:|...::.....::.|||.|...:..:|.||
Worm   414 VVASSIMRGRDNGVPPYNELRRTFGL-APKTWETMNEDFYKKHTAKVEKLKELYGGNILYLDAYV 477

  Fly   518 GGMLESYGQ--PGEFFTAVIKEQFQRLRDADRFWFENERNGIFTPEEIAELRKITLWDIIVNSTD 580
            |||||. |:  |||.|..:||:||.|:||.|||||||:.||:||.||:..:..|||.|||..:||
Worm   478 GGMLEG-GENGPGELFKEIIKDQFTRIRDGDRFWFENKLNGLFTDEEVQMIHSITLRDIIKATTD 541

  Fly   581 VKEEEIQKDVFMWRTGDPCPQPMQLNATELEPCTYLEGYDYFSGSELMFIYVCVFLGFVPILCAG 645
            :.|..:|||||.::.|||||||.|:|.|.||||.......|::.::..:::..:.|..||::|.|
Worm   542 IDETMLQKDVFFFKEGDPCPQPFQVNTTGLEPCVPFMQSTYWTDNDTTYVFTLIGLACVPLICYG 606

  Fly   646 AGYCVVKLQNSKRRRLKIRQ----EALRAP------QHKGSVDKMLAREWLHANHKRLVTVKF-- 698
            .|..:|      .||:.|..    ::|...      ..||.:..:.|.|||...:.|.|.::.
Worm   607 IGRYLV------NRRIAIGHNSACDSLTTDFANDDCGAKGDIYGVNALEWLQEEYIRQVRIEIEN 665

  Fly   699 ------GPEAAIYTVDR--KGEKLRTFSLKHIDVVSVEESATNHIKKKPYILLRVPSDHDLVLEL 755
                  .|...|....|  .|:|:..|.       |:...:..|   .|::||...::|.||:.|
Worm   666 TTLAVKKPRGGILRKIRFETGQKIELFH-------SMPNPSAMH---GPFVLLSQKNNHHLVIRL 720

  Fly   756 ESYGARRKFVKKLEDFLLLHKKEMTLMEVNRDIMLARAETRERRQKRLEYFFREAYALTFGLRPG 820
            .|.....||:.::.........|:.:.:....|:|::|.|:||||.||:.|||||||..|.   .
Worm   721 SSDRDLSKFLDQIRQAASGINAEVIIKDEENSILLSQAITKERRQDRLDLFFREAYAKAFN---D 782

  Fly   821 ERRRRSDASSDGEVMTVMRTSLSKAEFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVV 885
            ...:.|:.|.|.....::..::|:.|.|:|:|||.|:.||::||.:..|..:..:||.|||..:.
Worm   783 SELQDSETSFDSSNDDILNETISREELASAMGMKANNEFVKRMFAMTAKHNEDSLSFNEFLTVLR 847

  Fly   886 LFSRGKTDDKLRIIFDMCDNDRNGVIDKGELSEMMRSLVEIARTTSLGDDQVTELID-GMFQDV- 948
            .|.......||:.:|.|||.:....:.:.:|:|:::||.:.|..      .:||.:. .:|.:|
Worm   848 EFVNAPQKQKLQTLFKMCDLEGKNKVLRKDLAELVKSLNQTAGV------HITESVQLRLFNEVL 906

  Fly   949 ---GLEH-KNHLTYQDFKLMMKEYKGDFVAIGLDCKGAKQNFLDTSTNVARMTSFNI--EPMQDK 1007
               |:.: ..:|||.||..:..:.. |...:||...  ::|:..:....:.:.||.:  ..:...
Worm   907 HYAGVSNDAKYLTYDDFNALFSDIP-DKQPVGLPFN--RKNYQPSIGETSSLNSFAVVDRSINSS 968

  Fly  1008 PRHWLLAKWDAYITFLEENRQNIFYLFLFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITR 1072
            ....|:.|..|   |||..||::|.:|.|..:.:|||.|||.||.:|||:.|||.:||.||||||
Worm   969 APLTLIHKVSA---FLETYRQHVFIVFCFVAINLVLFFERFWHYRYMAENRDLRRVMGAGIAITR 1030

  Fly  1073 GSAASLSFCYSLLLLTMSRNLITKLKEFPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNF 1137
            |:|.:||||.:|:|||:.||:||.|:|..|.||||.||.|.||||.|..|.|::.||||||.|||
Worm  1031 GAAGALSFCMALILLTVCRNIITLLRETVIAQYIPFDSAIAFHKIVALFAAFWATLHTVGHCVNF 1095

  Fly  1138 YHVSTQSHENLRCLTREVHFASDYKPDITFWLFQTVTGTTGVMLFIIMCIIFVFAHPTIRKKAYN 1202
            |||.|||.|.|.||.:|..|.|::.|.|::|.|.|:||.||:.|..:||||:|||.|...|:||:
Worm  1096 YHVGTQSQEGLACLFQEAFFGSNFLPSISYWFFSTITGLTGIALVAVMCIIYVFALPCFIKRAYH 1160

  Fly  1203 FFWNMHTLYIGLYLLSLIHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYMALDVIDTDLLP 1267
            .|...|.|.|..|.|:|:|||.:|...|:|..:.:||.:::.:|:|:.|...|..|::::.::||
Worm  1161 AFRLTHLLNIAFYALTLLHGLPKLLDSPKFGYYVVGPIVLFVIDRIIGLMQYYKKLEIVNAEILP 1225

  Fly  1268 SDVIKIKFYRPPNLKYLSGQWV-----RLSCTAFRPHEMHSFTLTSAPHENFLSCHIKAQGPWTW 1327
            ||:|.|::.||...||.|||||     .:|||.   :|.|:|::.|:|.:..:..:|||.|||||
Worm  1226 SDIIYIEYRRPREFKYKSGQWVTVSSPSISCTF---NESHAFSIASSPQDENMKLYIKAVGPWTW 1287

  Fly  1328 KLRNYFDPCNYNPEDQPKIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNR 1392
            |||:............|.|.::||:|.|||:|..:|||:|||.|||||||||.|.|||..||::.
Worm  1288 KLRSELIRSLNTGSPFPLIHMKGPYGDGNQEWMDYEVAIMVGAGIGVTPYASTLVDLVQRTSSDS 1352

  Fly  1393 YSGVACKKVYFLWICPSHKHFEWFIDVLRDVEKKDVTNVLEIHIFITQFFHKFDLRTTMLYICEN 1457
            :..|.|:||||||:|.:||::|||:|||::||.:..:.:||.|||:||.|||||||||||||||.
Worm  1353 FHRVRCRKVYFLWVCSTHKNYEWFVDVLKNVEDQARSGILETHIFVTQTFHKFDLRTTMLYICEK 1417

  Fly  1458 HFQRL-SKTSIFTGLKAVNHFGRPDMSSFLKFVQKKHSYVSKIGVFSCGPRPLTKSVMSACDEVN 1521
            ||:.. |..|:||||.|.||||||:..:|.:|:|.:|...||||||||||..|.:|:...|.:.|
Worm  1418 HFRATNSGISMFTGLHAKNHFGRPNFKAFFQFIQSEHKEQSKIGVFSCGPVNLNESIAEGCADAN 1482

  Fly  1522 KTRKLPYFIHHFENF 1536
            :.|..|.|.|.||.|
Worm  1483 RQRDAPSFAHRFETF 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139	248/516 (48%)
		dual_peroxidase_like	72..625	CDD:188652	269/559 (48%)
		EFh	827..882	CDD:238008	19/54 (35%)
		EFh	860..921	CDD:238008	18/60 (30%)
		EF-hand_7	860..920	CDD:290234	18/59 (31%)
		EFh	895..966	CDD:238008	21/76 (28%)
		EF-hand_7	899..965	CDD:290234	19/71 (27%)
		Ferric_reduct	1084..1217	CDD:280043	73/132 (55%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	144/276 (52%)
bli-3	NP_490686.3	An_peroxidase	28..542	CDD:281139	249/518 (48%)
		dual_peroxidase_like	31..586	CDD:188652	269/559 (48%)
		FRQ1	784..932	CDD:227455	43/154 (28%)
		Ferric_reduct	1035..1176	CDD:280043	77/140 (55%)
		NOX_Duox_like_FAD_NADP	1218..1402	CDD:99783	90/186 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166239
Domainoid	1	1.000	520	1.000	Domainoid score	I152
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9689
Inparanoid	1	1.050	1220	1.000	Inparanoid score	I90
Isobase	1	0.950	-	0	Normalized mean entropy	S4061
OMA	1	1.010	-	-		QHG46390
OrthoDB	1	1.010	-	-		D19296at33208
OrthoFinder	1	1.000	-	-		FOG0000155
OrthoInspector	1	1.000	-	-		otm14415
orthoMCL	1	0.900	-	-		OOG6_100242
Panther	1	1.100	-	-	LDO	PTHR11972
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R458
SonicParanoid	1	1.000	-	-		X184
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750