DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Duox and nox5

DIOPT Version :9

Sequence 1:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster
Sequence 2:	XP_017209809.1	Gene:	nox5 / 100149800	ZFINID:	ZDB-GENE-091120-9	Length:	775	Species:	Danio rerio

Alignment Length:	817	Identity:	202/817 - (24%)
Similarity:	340/817 - (41%)	Gaps:	198/817 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   846 EFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGV 910
            ||..||.:| ...|..:.|.:.|.|....||..|.|:.:.|...|...||||.:|.:.|.|.:|.
Zfish    31 EFKTALKVK-ESFFAERFFALFDSDGSSSISLDELLKALDLLIHGTETDKLRFLFQVYDVDGSGS 94

  Fly   911 IDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAI 975
            ||..||..:::|.:. ....||.::::.:|...:|:....::...:|:::.|..:
Zfish    95 IDPDELRTVLKSCLR-ESAISLPEEKLDDLTLALFESADKDNSGSITFEELKAEL---------- 148

  Fly   976 GLDCKGAKQNFLDTSTNVARMTSFNIEP---MQDK---PRHWLLAKWDAYITFLEENRQNIFYLF 1034
                    :.|.:...|:....:..::|   .|:|   ||:...|.|       ..|.:.:|:|.
Zfish   149 --------ETFPEVMENLTISAANWLKPPDLEQNKRKTPRYLTRAYW-------HNNSRKLFFLC 198

  Fly  1035 LFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKE 1099
            |:.::...||:      ..|.:|.|    .|:.|.:.||....|:...:.:::.|.|..:|.|:.
Zfish   199 LYGLLNTFLFI------MAMLKHAD----GGLWIMLARGCGQCLNLNCTFVMVLMLRRCLTWLRA 253

  Fly  1100 FPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVST-----QSHENLRCLTREVHFAS 1159
            ..:.:.:|||.:|..|:|.....|.|||.||..||:||..:|.     |..|.|..:
Zfish   254 TWVVRVLPLDQNILLHQIVGYAILIFSVGHTGAHIMNFARLSQNDGAYQLWEYLFTI-------- 310

  Fly  1160 DYKPDITFWLFQTVTGT---TGVMLFIIMCIIFVFAHPTIRKKAY--NFFWNMHTLYIGLYLLSL 1219
              :|.|. |    |.||   |||::.|::.::.|.:...:|:..:  .|:|: |..||.:..|.:
Zfish   311 --RPGIG-W----VNGTASITGVVIQILIGLMVVCSSTFVRRSGHFEVFYWS-HLSYIWVSALLV 367

  Fly  1220 IHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYM-ALDVIDTDLLPSDVIKIKFYRPPNLKY 1283
            :|       ...||.:|:.||:.:.::|:|.:....| .|.:::.:||||.|..:...|||..::
Zfish   368 VH-------CANFWKWFVVPGVAFLIEKLVGIAVSRMGGLYIVEVNLLPSKVTHLVIKRPPFFQF 425

  Fly  1284 LSGQWVRLSCTAFRPHEMHSFTLTSAP-HENFLSCHIKAQGPWTWKLRNYF-DP----------- 1335
            ..|.:|.::......:|.|.||::||| .:..|..||::.|.||.:|..|| .|
Zfish   426 KPGDYVYINIPTIAKYEWHPFTISSAPEQQETLWLHIRSMGQWTNRLYEYFRQPDTQTNKRLTAS 490

  Fly  1336 -------------------C-------------------------NYNPEDQP------------ 1344
                               |                         :.||...|
Zfish   491 LRSRRHQSRAQEEMFRSASCRGSVASNKDDAVELTMYRTNGTRRNSQNPVCDPAAQAELGDASLA 555

  Fly  1345 -----------------KIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNR 1392
                             |..::||||...:..:..|.|:::|.|||:||:||||..::......:
Zfish   556 TRELTAKLSENHRYCNIKCYVDGPFGTPTRQIFASEHAILIGAGIGITPFASILQSIMCRYRMRK 620

  Fly  1393 YSGVAC---------------KKVYFLWICPSHKHFEWFIDVLRDVE-----KKDVTNVLEIHIF 1437
            .:...|               :||.|:||....|.||||:.:|..:|     ::.....||:|::
Zfish   621 QNCPNCSYSWCETIKDNEMKLRKVDFIWINRDQKSFEWFVSLLTKLEMDQADEEPEGRFLEMHMY 685

  Fly  1438 ITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSS-FLKFVQKKHSYVSKIGV 1501
            :|....|.|::...|.:..:...:..|....|||:.....||||.:. |.|..::|.   .|:.|
Zfish   686 MTSALSKNDMKAIGLQMALDLLAKKEKRDSITGLRTRTQPGRPDWAKVFQKVSEEKK---GKVHV 747

  Fly  1502 FSCGPRPLTKSVMSACDEVNKTRKLPYFIHHF--ENF 1536
            |.||...|.|.:.:.|:.         |..||  |||
Zfish   748 FYCGSPALAKVIKAQCER---------FGFHFYKENF 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	12/35 (34%)
		EFh	860..921	CDD:238008	21/60 (35%)
		EF-hand_7	860..920	CDD:290234	21/59 (36%)
		EFh	895..966	CDD:238008	18/70 (26%)
		EF-hand_7	899..965	CDD:290234	15/65 (23%)
		Ferric_reduct	1084..1217	CDD:280043	41/142 (29%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	91/379 (24%)
nox5	XP_017209809.1	EFh	44..105	CDD:238008	21/60 (35%)
		EF-hand_7	44..100	CDD:290234	19/55 (35%)
		EFh	79..146	CDD:238008	17/67 (25%)
		EF-hand_7	80..146	CDD:290234	16/66 (24%)
		Ferric_reduct	231..366	CDD:280043	42/150 (28%)
		NOX_Duox_like_FAD_NADP	402..775	CDD:99783	91/384 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810