DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment G6P and G6PC3

DIOPT Version :9

Sequence 1:	NP_001097063.1	Gene:	G6P / 33476	FlyBaseID:	FBgn0031463	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_612396.1	Gene:	G6PC3 / 92579	HGNCID:	24861	Length:	346	Species:	Homo sapiens

Alignment Length:	353	Identity:	89/353 - (25%)
Similarity:	148/353 - (41%)	Gaps:	52/353 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TTLTRELFINEWAQERLSFGRPLWHFLSVHLEPNKMFNIIIPLCGIFSQEILVHLFTAFTLISTL 78
            :||...:.|.|..|.:|::...:|.:::...:|..:|....|.....|:.:.:.:.....:...|
Human     3 STLGAGIVIAEALQNQLAWLENVWLWITFLGDPKILFLFYFPAAYYASRRVGIAVLWISLITEWL 67

  Fly    79 NSFEKWIYPETRPLWFLREQFANNVVVKKPAVALESHQL--SCEMTGGLPCAHSM----TFTVFV 137
            |...||.....||.|::.|   :....:.||   :.||.  |||...|.|..|.|    .....:
Human    68 NLIFKWFLFGDRPFWWVHE---SGYYSQAPA---QVHQFPSSCETGPGSPSGHCMITGAALWPIM 126

  Fly   138 LILASFFFVHCWDRFAALRSSFCRCIMYLLIIGMVVCMWLSRLYLATEFLHQCILGSYLGIRSLC 202
            ..|:|........|:..:..|...| .:||.:|      |||:::...|.||.:.|       |.
Human   127 TALSSQVATRARSRWVRVMPSLAYC-TFLLAVG------LSRIFILAHFPHQVLAG-------LI 177

  Fly   203 TFEGNVKYLFSRPR--------RYAVSAVFFLGGLALSVYYVKLELNIDPHWSVREAFKWCPEPT 259
            |  |.|......||        .|.::|:..:.|.:| :|:....|.:|..||:..|||||..|.
Human   178 T--GAVLGWLMTPRVPMERELSFYGLTALALMLGTSL-IYWTLFTLGLDLSWSISLAFKWCERPE 239

  Fly   260 YLRHEVGPIFALVRDLGNLMGL--ALASPLYKLEMKQSSFWRRCR---------FLGVLEFVNYG 313
            ::..:..|..:|.||.|..:||  ||.||.| .:::::......:         .||.|:::.:.
Human   240 WIHVDSRPFASLSRDSGAALGLGIALHSPCY-AQVRRAQLGNGQKIACLVLAMGLLGPLDWLGHP 303

  Fly   314 LRFSTFKQSGRFVFLTYEFLRNVIHSLV 341
            .:.|.|.   .|.||.|.....::.:||
Human   304 PQISLFY---IFNFLKYTLWPCLVLALV 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G6P	NP_001097063.1	PAP2_glucose_6_phosphatase	49..290	CDD:239476	70/256 (27%)
G6PC3	NP_612396.1	PAP2_glucose_6_phosphatase	38..270	CDD:239476	69/254 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146784
Domainoid	1	1.000	52	1.000	Domainoid score	I11461
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I5024
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49592
OrthoDB	1	1.010	-	-		D325559at33208
OrthoFinder	1	1.000	-	-		FOG0001425
OrthoInspector	1	1.000	-	-		otm42077
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12591
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5586
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	11.000