DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment G6P and G6pc2

DIOPT Version :9

Sequence 1:	NP_001097063.1	Gene:	G6P / 33476	FlyBaseID:	FBgn0031463	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_067306.1	Gene:	G6pc2 / 14378	MGIID:	1277193	Length:	355	Species:	Mus musculus

Alignment Length:	314	Identity:	86/314 - (27%)
Similarity:	129/314 - (41%)	Gaps:	56/314 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IVHILSDAYHTTLTRELFINEWAQERLSFGRPLWHFLSVHLEPNKMFNIIIPLCGIFSQEILVHL 68
            |:|.|.:.|.|...   |:|               |:|...:|..:|:|..||....:|.:...:
Mouse    11 IIHHLQEDYRTYYG---FLN---------------FMSNVGDPRNIFSIYFPLWFQLNQNVGTKM 57

  Fly    69 FTAFTLISTLNSFEKWIYPETRPLWFLREQFANNVVVKKPAVALESHQLSCEMTGGLPCAHSM-- 131
            .....:....|...|||....||.|:::|   ..:.....:..||....:||...|.|..|:|
Mouse    58 IWVAVIGDWFNLIFKWILFGHRPYWWIQE---TEIYPNHSSPCLEQFPTTCETGPGSPSGHAMGS 119

  Fly   132 TFTVFVLILASFFF-----------VHCWDRFAALRSSFCRCIMYLLIIGMVVCMWLSRLYLATE 185
            :...:|::.|:..:           :|      .|..||...:.:|:.|.  ||  :||:::||.
Mouse   120 SCVWYVMVTAALSYTISRMEESSVTLH------RLTWSFLWSVFWLIQIS--VC--ISRVFIATH 174

  Fly   186 FLHQCILGSYLGIRSLCTFEGNVKYLFSRPRRYAVSAVF-FLGGLALSVYYVKLEL-NIDPHWSV 248
            |.||.|||...|:.....||.......:....|..:.|| ||..|.   :|:.|.| .||..|||
Mouse   175 FPHQVILGVIGGMLVAEAFEHTPGVHMASLSVYLKTNVFLFLFALG---FYLLLRLFGIDLLWSV 236

  Fly   249 REAFKWCPEPTYLRHEVGPIFALVRDLGNLMGLALASPLYKLEMKQSSFWRRCR 302
            ..|.|||..|.::..:..|...|||:||.|.||..|       :....|.|.|:
Mouse   237 PIAKKWCANPDWIHIDSTPFAGLVRNLGVLFGLGFA-------INSEMFLRSCQ 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
G6P	NP_001097063.1	PAP2_glucose_6_phosphatase	49..290	CDD:239476	73/255 (29%)
G6pc2	NP_067306.1	PgpB	<36..193	CDD:223743	42/169 (25%)
		PAP2_glucose_6_phosphatase	38..278	CDD:239476	73/262 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	352..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836738
Domainoid	1	1.000	43	1.000	Domainoid score	I12314
eggNOG	1	0.900	-	-		E1_2CMVX
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5117
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49592
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001425
OrthoInspector	1	1.000	-	-		otm44130
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12591
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11645
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.860