DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2964 and PYK2

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_014992.3	Gene:	PYK2 / 854529	SGDID:	S000005874	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	505	Identity:	180/505 - (35%)
Similarity:	292/505 - (57%)	Gaps:	15/505 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TQLSHICELDLA--QQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKT 76
            ::|..:..|.:.  ||.   |..|:|.||...:.:.:.|..:...|:||.||||||.|:|.|...
Yeast     4 SRLQRLANLKIGTPQQL---RRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSV 65

  Fly    77 IELINEALERIHKETGQIRTVAIAADTRGPQIRTG--LLDGDVFLRSGDNLRLSINRDLYDKGNK 139
            ||   .|::...:..|  |.:|||.||:||:||||  |.|.|:::.....:..:.:....:..|.
Yeast    66 IE---NAVKSEQQFPG--RPLAIALDTKGPEIRTGRTLNDQDLYIPVDHQMIFTTDASFANTSND 125

  Fly   140 EAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVD--GLLCEVIHGGQLNNNCNVILPEIEID 202
            :.:|:||.|:..:...|..:::|||.|...:|:: :|  .|..:.::.|.:.::..|.||..::|
Yeast   126 KIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQI-IDESNLRVQAVNSGYIASHKGVNLPNTDVD 189

  Fly   203 LPAVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSE 267
            ||.:|.|||.|:||.::..:..:|||.:|::::|..:|..||.:|:.||||:|::::..|..|.|
Yeast   190 LPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDE 254

  Fly   268 ILRAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAECFD 332
            ||...||::::|.|||.:|...::...||.::.:||..|||||.|:.:|:||...|.|||||..|
Yeast   255 ILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSD 319

  Fly   333 LANAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAHSL 397
            :.||::|||||:|||.|.|.|.:|...|.........||..:....|:.||............::
Yeast   320 VGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETV 384

  Fly   398 AIAAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYTLE 462
            |.||.......:...|:||:|:|.:|.|:||:||.|||:.:||..||||..:|:|||.|.||..:
Yeast   385 AAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLYEPK 449

  Fly   463 PSTDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRV 512
            ...|:..||..|::|.:..|:.:|::|:||.:|.:..:|.|.|.:|.:|:
Yeast   450 RLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRI 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	176/485 (36%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	175/483 (36%)
PYK2	NP_014992.3	Pyruvate_Kinase	20..502	CDD:238178	176/489 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343742
Domainoid	1	1.000	115	1.000	Domainoid score	I1320
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S493
OMA	1	1.010	-	-		QHG53565
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		mtm9214
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	12	11.660