DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2964 and CDC19

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_009362.1	Gene:	CDC19 / 851193	SGDID:	S000000036	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	507	Identity:	196/507 - (38%)
Similarity:	297/507 - (58%)	Gaps:	19/507 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EGSTQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSK 75
            |..|.|:.:...||       |..|:|.||...:.|.:|:..:...|:||.|:||||.|:|.|..
Yeast     5 ERLTSLNVVAGSDL-------RRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKS 62

  Fly    76 TIELINEALERIHKETGQIRTVAIAADTRGPQIRTGLLDGDVFLRSGDNLRLSINRDLYDKGNK- 139
            .|:...::     :|....|.:|||.||:||:||||....||......|..:....|  ||..|
Yeast    63 VIDNARKS-----EELYPGRPLAIALDTKGPEIRTGTTTNDVDYPIPPNHEMIFTTD--DKYAKA 120

  Fly   140 ---EAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLL-CEVIHGGQLNNNCNVILPEIE 200
               :.:||||.||..:...|..:::|||.|...:|||..|..| .:.::.|::.::..|.||..:
Yeast   121 CDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNLPGTD 185

  Fly   201 IDLPAVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRF 265
            :||||:||||..|::|.:|..|..:|||.:|:|.:|..:|.||||:||.:|||.|::::..::.|
Yeast   186 VDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQGVNNF 250

  Fly   266 SEILRAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAEC 330
            .|||:..||::::|.|||.:||..::...||.::.:.|..|||||.|:.:||||...|.|||||.
Yeast   251 DEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEV 315

  Fly   331 FDLANAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAH 395
            .|:.|||:|||||:|||.|.|.|::|...|.|.......||:.:.:...:.|:.:..........
Yeast   316 SDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPTSTTE 380

  Fly   396 SLAIAAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYT 460
            ::|.:||.......|..||||:|||.:..||||:||.|||:.:|||.|.||:.:|:|||.|.::.
Yeast   381 TVAASAVAAVFEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRGVFPFVFE 445

  Fly   461 LEPSTDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRV 512
            .||.:|:..||:||:.|.:..||::||:..||..|.:..:|.|.|.:|.::|
Yeast   446 KEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	191/486 (39%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	190/484 (39%)
CDC19	NP_009362.1	Pyruvate_Kinase	18..500	CDD:238178	192/494 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343741
Domainoid	1	1.000	115	1.000	Domainoid score	I1320
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53565
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		mtm9214
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	11	10.710