DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2964 and PKP-ALPHA

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_566720.1	Gene:	PKP-ALPHA / 821870	AraportID:	AT3G22960	Length:	596	Species:	Arabidopsis thaliana

Alignment Length:	524	Identity:	158/524 - (30%)
Similarity:	255/524 - (48%)	Gaps:	51/524 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SLSAKSVLKEGS-TQLSHICELDLAQQASHQ-RLVSLIATISVSSRNADTIYTMIMRGVNIFRLN 64
            |:.|.:|..:.| .::..:.|.:|.:..... |...||.||..::...:.:..:.:.|:|:.|||
plant    85 SVVATAVTTDTSGIEVDTVTEAELKENGFRSTRRTKLICTIGPATCGFEQLEALAVGGMNVARLN 149

  Fly    65 FSHESHEMHSKTIELINEALERIHKETGQIRTVAIAADTRGPQIRTGLLDGDVFLRSGDNLRLSI 129
            ..|.:.:.|...|    .::.|:::|.|  ..|||..||.|.:|..|.|.|:...::.|....:.
plant   150 MCHGTRDWHRGVI----RSVRRLNEEKG--FAVAIMMDTEGSEIHMGDLGGEASAKAEDGEVWTF 208

  Fly   130 NRDLYDKGNKE-AVYVDYPNIINLTKTGDRLFIDDGRLLLHILE-VGVDGLLCEVIHGGQLNNNC 192
            ....:|....| .:.|.|.......:.||.|.:|.|.:...::| :|.| :.|.....|.|....
plant   209 TVRAFDSSRPERTISVSYDGFAEDVRVGDELLVDGGMVRFEVIEKIGPD-VKCLCTDPGLLLPRA 272

  Fly   193 NV-------ILPEIEIDLPAVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLG--EKGK 248
            |:       ::.|....||.:|.||..||.|.|...|||:..|.|:||:.:..|::.|.  .:|.
plant   273 NLTFWRDGSLVRERNAMLPTISSKDWLDIDFGIAEGVDFIAVSFVKSAEVINHLKSYLAARSRGG 337

  Fly   249 HIKIIAKMDSKIALSRFSEILRAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVAS 313
            .|.:|||::|..:|:...||:.|:||.:::|.|||.|||:|::...|:.|:..|..:.|||||||
plant   338 EIGVIAKIESIDSLTNLEEIILASDGAMVARGDLGAQIPLEQVPAAQQRIVQVCRALNKPVIVAS 402

  Fly   314 HILESMRTLPHPTRAECFDLANAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRD 378
            .:||||...|.|||||..|::.|:...:|.:|||.|.|:|.||.:.:....|:....|:  |:|:
plant   403 QLLESMIEYPTPTRAEVADVSEAVRQRSDALMLSGESAMGQFPDKALTVLRTVSLRIER--WWRE 465

  Fly   379 --------------LFSDLVSEVRGELDAAHSLAIAAVETAKRTNATLIIVLTTSGRSATLVSKF 429
                          .|||.:||         .:..:|.:.|.......:.|.||||..|:|||:.
plant   466 EKRHESVPLQAIGSSFSDKISE---------EICNSAAKMANNLGVDAVFVYTTSGHMASLVSRC 521

  Fly   430 RPRCPIMAITRCERTARWVYLHRGVLPILYTLEPSTDYATDVDARVQFAMTSAKKWGIIDDGDPI 494
            ||.|||.|.|......|.:.|..|::|.      ...::.|:::.:....:..|..|:|..||.:
plant   522 RPDCPIFAFTTTTSVRRRLNLQWGLIPF------RLSFSDDMESNLNKTFSLLKSRGMIKSGDLV 580

  Fly   495 VIVS 498
            :.||
plant   581 IAVS 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	152/492 (31%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	152/492 (31%)
PKP-ALPHA	NP_566720.1	PLN02762	93..596	CDD:215407	155/516 (30%)
PKP-ALPHA	NP_566720.1	Pyruvate_Kinase	117..584	CDD:304951	150/490 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933620at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880