DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2964 and CG12229

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_648980.1	Gene:	CG12229 / 39945	FlyBaseID:	FBgn0036723	Length:	571	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	109/540 - (20%)
Similarity:	207/540 - (38%)	Gaps:	99/540 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKTIELINEALERIHKETGQIR-TV 97
            :.|:|.: |:....|.:..|:..|...|.::......:.....::.:|.|:. .|....::| |.
  Fly    75 LGLVAKL-VTETTHDELRRMLENGTYTFHVDTVGNKPDELKAILDTMNIAIS-AHSAERELRLTT 137

  Fly    98 AIAADTRGPQIRTGLLDGD--VFLRSGDNLRLSINRDLYDKGNKEAVYVDYPNIINL------TK 154
            .:|.:..|...|.|.|..:  |.|..|..:.|:.:.....||.||.|||     |||      .:
  Fly   138 GLALEINGECCRVGRLRNNCTVMLARGGVVTLTTDESYRYKGFKEIVYV-----INLRCYLASVQ 197

  Fly   155 TGDRLFIDDGRLLL-HILEVGVDGLLCEVIHGG--------QLNNNCNVILPEIEIDLPAVSEKD 210
            .||.:.|  ||.:. .:::...:.|...:|..|        :|...|:.:.|::..||      .
  Fly   198 LGDIVMI--GREVRGKVVKTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDL------Y 254

  Fly   211 MFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSEILRAADGL 275
            |.|::.:...|.:::....:|....::.:|..| ....::|:|..:|.:...|...::|    |:
  Fly   255 MKDLEMAASLNANYVVLPKIRCKSFLRAVRQTL-NSDFNLKLIGMIDFEYVRSNMLDLL----GI 314

  Fly   276 LLSRADLGTQIPIEKLFITQKSI----------LGQCNKVGKPVIVASHILESMRTLPHPTRAEC 330
            :    .|...|.|..:|.....:          :.||.|  ||||         .|:|   ...|
  Fly   315 I----KLVDYIWIPDMFNVNCCVYNYIMEDVLPISQCQK--KPVI---------GTVP---LERC 361

  Fly   331 FDLANAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSE---VRGELD 392
            .|...  .:..|.:.....:.|...|     .|:......:|::..:|.....|..   ::..|.
  Fly   362 SDFKR--FELHDFLWKVDAIHIQKSP-----WCNKYPLIVKKLMPIKDYRVGAVQNKMVLKSILT 419

  Fly   393 AAHSLAIAAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERT------------A 445
            :..::....:.|........|.:.||...::..:|:....||:..:...|.|            |
  Fly   420 SYQTIVNFIIRTISSIECQAIFLFTTCETASVALSRIEIYCPVYVMVPLEETDDAETITCKVELA 484

  Fly   446 RWVYLHRGVLPILYTLE-PSTDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGG----- 504
            |.::|.|.:.|:|||.: ....|:.     ::|.:...:|.|.::.||.:|.:...|:..
  Fly   485 RALHLRRNMHPVLYTKDLNECSYSP-----IEFGVDFMRKKGCLEVGDFVVTLEVGKEDKDNVVI 544

  Fly   505 GFTNNVRVVYAFFEADRVDC 524
            |...:|.::.||:.:....|
  Fly   545 GIGEDVCILRAFYVSPLFAC 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	106/529 (20%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	106/526 (20%)
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	95/475 (20%)
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:304951	93/451 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910