DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2964 and Pklr

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	XP_006501198.1	Gene:	Pklr / 18770	MGIID:	97604	Length:	598	Species:	Mus musculus

Alignment Length:	504	Identity:	227/504 - (45%)
Similarity:	324/504 - (64%)	Gaps:	4/504 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKTIE 78
            |.|.|:|.||:..:....|..|:||||..:||:.|.:..||..|:||.||||||.|||.|:::|.
Mouse    92 TFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIA 156

  Fly    79 LINEALERIHKETGQIRTVAIAADTRGPQIRTGLLDG----DVFLRSGDNLRLSINRDLYDKGNK 139
            .|.||.|.........|.||||.||:||:||||:|.|    :|.:..|..:.::::.....:|:.
Mouse   157 NIREAAESFATSPLSYRPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDA 221

  Fly   140 EAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLLCEVIHGGQLNNNCNVILPEIEIDLP 204
            :.|:|||.||..:...|.|::||||.:.|.:.::|.:||:.||.|||.|.|...|.||..|:|||
Mouse   222 KTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLP 286

  Fly   205 AVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSEIL 269
            .:||:|:.|::|.::.|||.:|||.||.|.:|..:|..||.:|:.||||:|:::...:.:|.|||
Mouse   287 GLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEIL 351

  Fly   270 RAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAECFDLA 334
            ..:||::::|.|||.:||.||:|:.||.::|:||..||||:.|:.:||||.|...|||||..|:|
Mouse   352 EVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDVA 416

  Fly   335 NAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAHSLAI 399
            ||::|||||||||.|.|.||||.|.|.....:.||||..::.|.||.:|........|.....||
Mouse   417 NAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAI 481

  Fly   400 AAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYTLEPS 464
            .|||.:.:..|..|||||.:||||.|:|::|||..::|:||..:.||.|:|.|||.|:||...|.
Mouse   482 GAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLLYREPPE 546

  Fly   465 TDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRVV 513
            ..:|.|||.||||.:.|.|..|.:..||.:::|:.|:.|.|:||.:||:
Mouse   547 AVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	221/486 (45%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	219/483 (45%)
Pklr	XP_006501198.1	Pyruvate_Kinase	109..597	CDD:238178	221/487 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836951
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S493
OMA	1	1.010	-	-		QHG53565
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.660