DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2964 and pyk-2

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001255515.1	Gene:	pyk-2 / 177984	WormBaseID:	WBGene00014001	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	506	Identity:	205/506 - (40%)
Similarity:	314/506 - (62%)	Gaps:	9/506 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 STQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVNIFRLNFSHESHEMHSKTI 77
            :|.:||:|.|.::::....|...:|.||..:..:.:|:..||..|:||.||||||.:||.|:.||
Worm    15 TTNISHLCGLRISERPQKTRKTGVICTIGPACSDVETLRKMINTGMNIARLNFSHGTHEAHAATI 79

  Fly    78 ELINEALERIHKETGQIRTVAIAADTRGPQIRTGLLDG---DVFLRSGDNLRLSINRDLYDKGNK 139
            :.|.||.|...      ..||||.||:||:||||:...   :|.|.:|.::|:|.:..:......
Worm    80 KTIREAAENAP------FPVAIALDTKGPEIRTGMFANNMKEVQLENGKSVRVSTDPSMEFAATS 138

  Fly   140 EAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLLCEVIHGGQLNNNCNVILPEIEIDLP 204
            ..:|.||.|:..:.:.|.|::||||.:.|.:.......::|.:.:||.|.....|.||...:|||
Worm   139 SHIYADYRNLPKVVQPGSRIYIDDGLISLIVESCEETAVICTIENGGALGTRKGVNLPGTIVDLP 203

  Fly   205 AVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKHIKIIAKMDSKIALSRFSEIL 269
            ||:.||:.|:.|.::..||.:|||.:|:|..:.::|.|||||||||.||||::|:..::...||:
Worm   204 AVTSKDIEDLLFGVEQGVDIIFASFIRNADGIHKIRQVLGEKGKHIYIIAKIESEDGVTNCDEII 268

  Fly   270 RAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASHILESMRTLPHPTRAECFDLA 334
            .|:||::::|.|||.:||.||:|:.||.::.:||..|||||.|:.:||||.|.|.||||||.|:|
Worm   269 EASDGVMVARGDLGIEIPAEKVFLAQKMLIAKCNLAGKPVICATQMLESMITKPRPTRAECSDVA 333

  Fly   335 NAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDLFSDLVSEVRGELDAAHSLAI 399
            ||::||.||:|||.|.|.|.:|.|.:|....:|:|||...:....|.:|:...:......|:.||
Worm   334 NAVLDGVDCVMLSGETAKGDYPVEALAIMHNICKEAESAFFHMKHFEELILHTKKPTGMTHTTAI 398

  Fly   400 AAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERTARWVYLHRGVLPILYTLEPS 464
            |||.......|..||::||:|::|.|.|::||..||:.::|.||.:|.::||||:.|:.|.....
Worm   399 AAVSATITCRAVAIILITTTGKTARLCSRYRPPVPIITVSRDERISRQLHLHRGIFPVYYPKGRI 463

  Fly   465 TDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNNVRVVYA 515
            .::..||:.|||:.:...|..|.|..|||:::::.||.|.||||.:|:|.|
Worm   464 DEWDVDVEERVQYGVNLGKTRGFIHLGDPLIVITGWKQGAGFTNTMRIVVA 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	199/485 (41%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	197/482 (41%)
pyk-2	NP_001255515.1	Pyruvate_Kinase	34..514	CDD:238178	199/485 (41%)
pyk-2	NP_001255515.1	pyruv_kin	34..511	CDD:273424	197/482 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860