DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2964 and pklr

DIOPT Version :9

Sequence 1:	NP_608713.2	Gene:	CG2964 / 33475	FlyBaseID:	FBgn0031462	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_958446.1	Gene:	pklr / 114551	ZFINID:	ZDB-GENE-010907-1	Length:	538	Species:	Danio rerio

Alignment Length:	524	Identity:	225/524 - (42%)
Similarity:	327/524 - (62%)	Gaps:	11/524 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSLSAKSVLKE------GSTQLSHICELDLAQQASHQRLVSLIATISVSSRNADTIYTMIMRGVN 59
            |:|....:.|:      ..|.|.|:|.||:.|:....|..|:|.||..:||:...:..|:..|:|
Zfish    12 MALPDSFIQKQQLDASMADTFLEHLCLLDIDQEPITARNTSIICTIGPASRSITKLQEMVKAGMN 76

  Fly    60 IFRLNFSHESHEMHSKTIELINEALERIHKETGQIRTVAIAADTRGPQIRTGLL----DGDVFLR 120
            |.||||||.:|:.|::||..:.||:|.:..:....|.||||.||:||:|||||:    |.:|.|.
Zfish    77 IARLNFSHGTHQYHAETIRNVREAVETLTSDPLYYRPVAIALDTKGPEIRTGLVKGRADAEVTLE 141

  Fly   121 SGDNLRLSINRDLYDKGNKEAVYVDYPNIINLTKTGDRLFIDDGRLLLHILEVGVDGLLCEVIHG 185
            .|..:|:.......::.:...:::|||::..:.|...|::||||.|.|.:||:|...|...|.:|
Zfish   142 RGALVRVVTAECEREQTDGSVIWMDYPSLTRVLKKDSRIYIDDGLLALRVLEIGDSWLQARVENG 206

  Fly   186 GQLNNNCNVILPEIE-IDLPAVSEKDMFDIQFSIKANVDFLFASAVRSAKNVKELRTVLGEKGKH 249
            |.|.::..|.||..| :|||||||:|..|:||.::..||.:|||.:|.|::|:.:|..||.:|..
Zfish   207 GVLGSSKGVNLPGAELLDLPAVSERDRSDLQFGVEQQVDMIFASFIRCAEDVRAVRDALGPQGHD 271

  Fly   250 IKIIAKMDSKIALSRFSEILRAADGLLLSRADLGTQIPIEKLFITQKSILGQCNKVGKPVIVASH 314
            ||||:|::|:..:..|.::|:.:||::::|.|||.:||.||:||.||.::|:||..|||||.|:.
Zfish   272 IKIISKVESRQGVRNFEQVLQESDGVMVARGDLGIEIPAEKVFIAQKMMIGRCNSAGKPVICATQ 336

  Fly   315 ILESMRTLPHPTRAECFDLANAIIDGADCIMLSSEVAIGSFPKETVATCDTLCREAEKVLWFRDL 379
            :||||.....|||||..|:|||::|||||:|||.|.|.|.||.|.||...::|||||..::.:.|
Zfish   337 MLESMVHHARPTRAESSDVANAVLDGADCVMLSGETAKGHFPVEAVAMMHSICREAEAAIFHQQL 401

  Fly   380 FSDLVSEVRGELDAAHSLAIAAVETAKRTNATLIIVLTTSGRSATLVSKFRPRCPIMAITRCERT 444
            |.:|........|.....||.|||::.:..|..||:||||||||.|:|::||||||:|:||..:.
Zfish   402 FEELRRLTPLSSDPTEVTAIGAVESSYKCCAGAIIILTTSGRSAQLLSRYRPRCPIIAVTRNAQV 466

  Fly   445 ARWVYLHRGVLPILYTLEPSTDYATDVDARVQFAMTSAKKWGIIDDGDPIVIVSAWKDGGGFTNN 509
            ||...|.|||.|.|:...|:..:|.|||.||.|||...|..|....||.:::|:.|..|.|.||.
Zfish   467 ARQSQLLRGVFPALFRAPPAEVWADDVDNRVTFAMDIGKARGFFRSGDMVIVVTGWSPGSGHTNI 531

  Fly   510 VRVV 513
            :|.|
Zfish   532 MRAV 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2964	NP_608713.2	Pyruvate_Kinase	32..515	CDD:304951	215/487 (44%)
CG2964	NP_608713.2	pyruv_kin	32..512	CDD:273424	213/484 (44%)
pklr	NP_958446.1	Pyruvate_Kinase	48..537	CDD:238178	215/488 (44%)
pklr	NP_958446.1	pyruv_kin	49..533	CDD:273424	213/483 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580481
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.720