DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment daw and DIA2

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_014723.2	Gene:	DIA2 / 854247	SGDID:	S000005606	Length:	732	Species:	Saccharomyces cerevisiae

Alignment Length:	612	Identity:	118/612 - (19%)
Similarity:	219/612 - (35%)	Gaps:	201/612 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 SQQLQ----QQHHIRQQRSRQLKHLEPDPTSEEDDVPITKREYYARLRRHVIHKRQ---HLLQQE 111
            |:.||    ..:|:|||:    :.::.:...::|.    ||.|...|....|.|::   ::|:..
Yeast   136 SRGLQLCNNDSNHLRQQK----QFIKNNMVQKQDG----KRSYIDPLEETKIAKKKKNNNVLESL 192

  Fly   112 LSYNHPGSHSEQLKVPRLWQHLMEQEEKAHRHVSPPVE-LPIMYG--DAPEESSLS------SDD 167
            ......||..:...|..|                 |:| |||::.  ...|..:||      .|.
Yeast   193 PKKKIKGSTKKTDLVGNL-----------------PIEILPIIFQRFTTKELVTLSLVCNKWRDK 240

  Fly   168 ---HFD-----DLSPLDFVRNELMAED--QQNQEKDLDLDLDLDQQPETPIEPELPLGERNITIS 222
               |.|     :|:|::| :|.:...|  |||..:..                     .:.|...
Yeast   241 ILYHLDCFQEFNLAPINF-KNFVKFMDFLQQNFTRTY---------------------RKYILSQ 283

  Fly   223 VKSSAGGCPKCESNRQVEHITEEQLTHLRIEFVKQQ---ILEKLRLKESPKVSAVELPKPIFDGM 284
            ||.|:             .||.|:|...::.|.|..   .:|:|.| ..|.::..::.|.:..|.
Yeast   284 VKVSS-------------RITSEELRITQLLFSKMPKCINIERLIL-SMPTLTTTQIFKLMVRGG 334

  Fly   285 TLSHPDDSTKNKELDDYYARTSKKFILL-----NREEVECNRARDGKSNPSMCFTFKI----DDA 340
            |              |::.|..:..:::     .:.|:|..:.........:.|...:    |..
Yeast   335 T--------------DFFTRLLELSLMITYRPDKQHELEILQTCPLLKKIELIFVNSLVPIFDGN 385

  Fly   341 DAEGFDVSTAVLWLFKNKQNRT---DTASVNSTSAQQTIVVSEVE-----VDQQKDSKY------ 391
            ::.|.|.|..|:....|.|..|   |...:    .::.::.||:|     .|::|...:
Yeast   386 NSVGRDGSFNVMARHTNMQISTADNDEQGI----VEEKVIYSELEKITLICDKKKIKNFPLCRAL 446

  Fly   392 ----LSAAKTIAIQSV----NVQD----EWMKIDIEWP-IKH-WISGH---ELSHLIQITCGGCD 439
                ....:.:.|..|    |.||    :|:   :.:| :|. ||..:   |||..:|:......
Yeast   447 LRGQFPLLQKLTITGVTFPMNNQDIMNFQWL---LNFPDLKELWIEDNDNCELSKFLQLLKFSNV 508

  Fly   440 VSDMEE----------IISVDKDYRP-----------FIVIDMQNRRRKSRQKRSINCSSGMTEC 483
            ..::|:          |:::|:| :|           |...::||..:......||: .|.:|..
Yeast   509 WKNLEKLTFRENKLYPIVNLDED-QPVTNDDEVPSMLFYKENLQNLEKLDLMGTSIS-GSALTRL 571

  Fly   484 CREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMK-ILSTSGANKSLEL 547
            | |..|:..|.:...|             .|:|.::    |..::|:...: ||..:...|.|
Yeast   572 C-EQEYLDGRKLRSLN-------------IGNCPNI----QFPNNHAHTARMILDVNAVLKRL-- 616

  Fly   548 VPCCTAKQYSSLQLVVMDSSNTATVKT 574
                  .:...:.|..:.|.|.:|:|:
Yeast   617 ------SKLEEINLSHLSSLNDSTMKS 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	50/277 (18%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	19/95 (20%)
DIA2	NP_014723.2	TPR repeat	19..43	CDD:276809
		TPR repeat	69..107	CDD:276809
		TPR repeat	112..140	CDD:276809	1/3 (33%)
		F-box	209..241	CDD:395521	10/48 (21%)
		leucine-rich repeat	483..511	CDD:275380	7/27 (26%)
		leucine-rich repeat	553..581	CDD:275381	7/29 (24%)
		leucine-rich repeat	582..618	CDD:275381	9/60 (15%)
		leucine-rich repeat	619..647	CDD:275381	5/19 (26%)
		leucine-rich repeat	648..673	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.807993	Normalized mean entropy	S5
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950