Protein Alignment daw and GDF5

DIOPT Version :10

• Sequence 1: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_000548.2
• Gene: GDF5 / 8200
• HGNCID: 4220
• Length: 501
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 103/485 - (21%)
• Similarity: 180/485 - (37%)
• Gaps: 123/485 - (25%)

  Fly   132 HLMEQEEKAHRHVSPPVELPIMYGDAPEESSLSSDDHFDDLSPLDFVRNELMAEDQQNQEKDLDL 196
            |..:..:...|.|:|..:||  .|.||.::.         ..|..|:
Human   110 HPPQTRQATARTVTPKGQLP--GGKAPPKAG---------SVPSSFL------------------ 145

  Fly   197 DLDLDQQPETPIEPELPLGERNIT-----ISVKSSAGGCPKCESNRQVEHITEEQLTHLRIEFV- 255
             |...::|..|.||:.|.....||     :|:..:.....:...|..|:  .|..|.:....|:
Human   146 -LKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVK--LEAGLANTITSFID 207

  Fly   256 -----------KQQILEKLRLKESPKVSAVELPKPIFDGMTLSHPDDSTKNKELDDYYARTSKKF 309
                       ||:.:..:...|...:...||      .:....|.|:.|........|
Human   208 KGQDDRGPVVRKQRYVFDISALEKDGLLGAEL------RILRKKPSDTAKPAAPGGGRA------ 260

  Fly   310 ILLNREEVECNRARDGKSNPSMCFTFKIDDADAEGFDVSTAVLW-LFKNKQNRTDTASVNSTSAQ 373
                 .:::.:....|:...::.....:...|..|::|..  :| ||:|.:|          |||
Human   261 -----AQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFD--IWKLFRNFKN----------SAQ 308

  Fly   374 QTIVVSEVEVDQQKDSKYLS---AAKTIAIQSV-NVQDEWMKIDIEWPIKHWISGHELSHLIQIT 434
            ..:.:...|..:..|.:.|.   ||:.:..::: .|.....|.|:            ..:.|:..
Human   309 LCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDL------------FFNEIKAR 361

  Fly   435 CGGCDVSDMEEIISVDKDYRPFIVIDMQNRRRK----SRQ-KR-SINCSSGMTECCREHLYISFR 493
            .|..|.:..|.:.|             |.|:|:    :|| || |.|..:   .|.|:.|:::|:
Human   362 SGQDDKTVYEYLFS-------------QRRKRRAPLATRQGKRPSKNLKA---RCSRKALHVNFK 410

  Fly   494 DIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVP--CCTAKQY 556
            |:||.:||:.|..|.|:.|.|.|..........::|:.|..::::...    |..|  ||...:.
Human   411 DMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDP----ESTPPTCCVPTRL 471

  Fly   557 SSLQLVVMDSSNTATVKTLPNMVVESCGCR 586
            |.:.::.:||:|....|...:|||||||||
Human   472 SPISILFIDSANNVVYKQYEDMVVESCGCR 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	32/103 (31%)
GDF5	NP_000548.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..169		18/88 (20%)
		PTZ00449	<90..>168	CDD:185628	17/87 (20%)
		TGFb_propeptide	145..>296	CDD:480997	27/190 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..265		4/29 (14%)
		TGF_beta_GDF5	399..501	CDD:381669	33/105 (31%)