Protein Alignment daw and TGFB1

DIOPT Version :10

• Sequence 1: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_011525544.1
• Gene: TGFB1 / 7040
• HGNCID: 11766
• Length: 391
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 98/401 - (24%)
• Similarity: 168/401 - (41%)
• Gaps: 79/401 - (19%)

  Fly   227 AGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVSAVELPKPIFDGMTLSHPDD 291
            |.|...|::      |..|.:...|||.::.|||.||||...|....|. |.|:.:.:...:  :
Human    27 AAGLSTCKT------IDMELVKRKRIEAIRGQILSKLRLASPPSQGEVP-PGPLPEAVLALY--N 82

  Fly   292 STKNKELD-----------DYYARTSKKFILLNREEVECNRARDGKSNPSMCF-TFKIDDADAEG 344
            ||:::...           ||||:...:.:::.......::.:....:..|.| |.::.:|..|.
Human    83 STRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEP 147

  Fly   345 FDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDS---KYLSAAKTIAIQSVNVQ 406
            ..:|.|.|.|.:.|..                |...||:.|:..:   :|||.    .:.:.:..
Human   148 VLLSRAELRLLRLKLK----------------VEQHVELYQKYSNNSWRYLSN----RLLAPSDS 192

  Fly   407 DEWMKIDIEWPIKHWIS-GHELSHL-IQITCGGCDVSDMEEIISVDKDY---------------R 454
            .||:..|:...::.|:| |.|:... :...| .||..|....:.::..:               |
Human   193 PEWLSFDVTGVVRQWLSRGGEIEGFRLSAHC-SCDSRDNTLQVDINAGFTTGRRGDLATIHGMNR 256

  Fly   455 PFIV-----IDMQNRRRKSRQKRSIN---C-SSGMTECCREHLYISFR-DIGWSNWILKPEGYNA 509
            ||::     ::.....:.||.:|:::   | ||....||...|||.|| |:|| .||.:|:||:|
Human   257 PFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGW-KWIHEPKGYHA 320

  Fly   510 YFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKT 574
            .||.|.|..:.|:.   :.:|.::.:.:..  |......|||..:....|.:|.. ......|:.
Human   321 NFCLGPCPYIWSLD---TQYSKVLALYNQH--NPGASAAPCCVPQALEPLPIVYY-VGRKPKVEQ 379

  Fly   575 LPNMVVESCGC 585
            |.||:|.||.|
Human   380 LSNMIVRSCKC 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	35/102 (34%)
TGFB1	XP_011525544.1	TGFb_propeptide	30..262	CDD:459906	54/261 (21%)
		TGF_beta_TGFB1	293..391	CDD:381654	36/105 (34%)