Protein Alignment daw and BMP8B

DIOPT Version :10

• Sequence 1: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: XP_011540326.2
• Gene: BMP8B / 656
• HGNCID: 1075
• Length: 427
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 100/438 - (22%)
• Similarity: 167/438 - (38%)
• Gaps: 122/438 - (27%)

  Fly   229 GCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPK----VSAVELP--KPIFDGMTLS 287
            |||            :.:|.......|:::||..|.|...|:    .:|..||  .|:| .:.|.
Human    30 GCP------------QRRLGARERRDVQREILAVLGLPGRPRPRAPPAASRLPASAPLF-MLDLY 81

  Fly   288 HP---DDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKSNPSMC-FTFKIDDADAEGFDVS 348
            |.   ||.......:....|.......:|.  ||.:||. |...|... |.|.:....| |..|:
Human    82 HAMAGDDDEDGAPAERRLGRADLVMSFVNM--VERDRAL-GHQEPHWKEFRFDLTQIPA-GEAVT 142

  Fly   349 TAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQSVNVQDE-WMKI 412
            .|...::|       ..|::..:  :|:.||..:|.|::.::. |....:.:|::...|| |:.:
Human   143 AAEFRIYK-------VPSIHLLN--RTLHVSMFQVVQEQSNRE-SDLFFLDLQTLRAGDEGWLVL 197

  Fly   413 DIE-----WPIKH----------------------WISGHELS---------------H------ 429
            |:.     |.:|.                      |.....|.               |
Human   198 DVTAASDCWLLKRHKDLGLRLYVETEDGETWTGWGWTKDSRLQMWKLRLSRTPWVLSLHAPGPAQ 262

  Fly   430 ------LIQITCGGCDVSDMEEIISVDKDYRPFIVIDMQNRRRKSRQKR-------------SIN 475
                  |:.:..|.|..|...  |...:..||.       |||:.::..             .::
Human   263 APAERPLLCLLQGHCPASPSP--IRTPRAVRPL-------RRRQPKKSNELPQANRLPGIFDDVH 318

  Fly   476 CSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHS---SIMKILS 537
            .|.|...|.|..||:||:|:||.:|::.|:||:||:|.|.||........|::|:   |::.::.
Human   319 GSHGRQVCRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMM 383

  Fly   538 TSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            .....|:     ||...:.|:..::..||||...::...||||::|||
Human   384 PDAVPKA-----CCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	35/104 (34%)
BMP8B	XP_011540326.2	TGFb_propeptide	33..226	CDD:459906	45/207 (22%)
		TGF_beta_BMP8	323..427	CDD:381668	37/109 (34%)