Protein Alignment daw and BMP7

DIOPT Version :10

• Sequence 1: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001710.1
• Gene: BMP7 / 655
• HGNCID: 1074
• Length: 431
• Species: Homo sapiens
• Alignment Length: 289
• Identity: 71/289 - (24%)
• Similarity: 125/289 - (43%)
• Gaps: 69/289 - (23%)

  Fly   343 EGFDVSTAVLWLFKNK-QNRTDTASVNSTSAQQTIVVSEVEVDQQK----------DSKYLSAAK 396
            ||..|:.|...::|:. :.|.|         .:|..:|..:|.|:.          ||:.|.|:
Human   165 EGEAVTAAEFRIYKDYIRERFD---------NETFRISVYQVLQEHLGRESDLFLLDSRTLWAS- 219

  Fly   397 TIAIQSVNVQDEWMKIDIEWPIKHWISG--HELSHLIQITCGGCDVSDMEEIIS------VDKDY 453
                     ::.|:..||.....||:..  |.|.  :|::....|...:...::      ..::.
Human   220 ---------EEGWLVFDITATSNHWVVNPRHNLG--LQLSVETLDGQSINPKLAGLIGRHGPQNK 273

  Fly   454 RPFIVI-------------------DMQNRRRKSRQKRSI-------NCSSGMTECCREH-LYIS 491
            :||:|.                   ..|||.:..:.:.::       |.||...:.|::| ||:|
Human   274 QPFMVAFFKATEVHFRSIRSTGSKQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVS 338

  Fly   492 FRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQY 556
            |||:||.:||:.||||.||:|.|.|:...:....|::|:.:..::..  .|......|||...|.
Human   339 FRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHF--INPETVPKPCCAPTQL 401

  Fly   557 SSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            :::.::..|.|:...:|...||||.:|||
Human   402 NAISVLYFDDSSNVILKKYRNMVVRACGC 430

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	36/102 (35%)
BMP7	NP_001710.1	TGFb_propeptide	35..280	CDD:459906	27/135 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..311		3/19 (16%)
		TGF_beta_BMP7	325..431	CDD:381667	38/108 (35%)