Protein Alignment daw and BMP5

DIOPT Version :9

• Sequence 1: NP_001259967.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_066551.1
• Gene: BMP5 / 653
• HGNCID: 1072
• Length: 454
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 98/443 - (22%)
• Similarity: 169/443 - (38%)
• Gaps: 141/443 - (31%)

  Fly   249 HLRIEFVKQQILEKLRLKESPK--------VSAVELPKPIFDGMTLSHPDDSTKNKELDDYYART 305
            |.|.| ::::||..|.|...|:        .||......:::.||      :.:|.|..:|..|.
Human    46 HERRE-IQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMT------NEENPEESEYSVRA 103

  Fly   306 SKKFILLNREEVECNRARDG----------------------KSNP--SMCFTFKIDDAD----- 341
            |.        ..|...||.|                      :|.|  |:..|..::|||
Human   104 SL--------AEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSF 160

  Fly   342 ---------------------------AEGFDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVS 379
                                       ..|..|:.|...::|::.        |:....:||.:|
Human   161 VNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRS--------NNRFENETIKIS 217

  Fly   380 EVEVDQQ---KDSKYLSAAKTIAIQSVNVQDEWMKIDIEWPIKHWISGHELSHLIQITCGGCDVS 441
            ..::.::   :|:. |....|...|:::|  .|:..||.....||:...:.:..:|:    |..:
Human   218 IYQIIKEYTNRDAD-LFLLDTRKAQALDV--GWLVFDITVTSNHWVINPQNNLGLQL----CAET 275

  Fly   442 DMEEIISV----------DKDYRPFIVI------------------DMQNRRRKSRQKRSINCS- 477
            .....|:|          .:..:||:|.                  ..|||.:.|..:.|...|
Human   276 GDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSS 340

  Fly   478 ------SGMTECCREH-LYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHHS---SI 532
                  |...:.|::| ||:||||:||.:||:.||||.|::|.|.||...:....|::|:   ::
Human   341 VGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTL 405

  Fly   533 MKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            :.::......|     |||...:.:::.::..|.|:...:|...||||.||||
Human   406 VHLMFPDHVPK-----PCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGC 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	52/285 (18%)
		TGF_beta	481..585	CDD:278448	36/107 (34%)
BMP5	NP_066551.1	TGFb_propeptide	32..304	CDD:395559	53/287 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..343		6/24 (25%)
		TGF_beta_BMP5	342..454	CDD:381665	39/117 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810