DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and GDF6

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001001557.1	Gene:	GDF6 / 392255	HGNCID:	4221	Length:	455	Species:	Homo sapiens

Alignment Length:	145	Identity:	40/145 - (27%)
Similarity:	70/145 - (48%)	Gaps:	20/145 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   452 DYRPFIVIDMQNRRR--------KSRQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYN 508
            |.||::....:.|||        |...|:|      ...|.::.|:::|:::||.:||:.|..|.
Human   321 DARPWLPSPGRRRRRTAFASRHGKRHGKKS------RLRCSKKPLHVNFKELGWDDWIIAPLEYE 379

  Fly   509 AYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVP--CCTAKQYSSLQLVVMDSSNTAT 571
            ||.|.|.|..........::|:.|..::::.....:    |  ||...:.:.:.::.:|:.|...
Human   380 AYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMDPGST----PPSCCVPTKLTPISILYIDAGNNVV 440

  Fly   572 VKTLPNMVVESCGCR 586
            .|...:|||||||||
Human   441 YKQYEDMVVESCGCR 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	3/5 (60%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	28/105 (27%)
GDF6	NP_001001557.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..93
		TGFb_propeptide	79..281	CDD:395559
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..267
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..351		9/35 (26%)
		TGF_beta_GDF5_6_7	354..455	CDD:381644	29/104 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810