DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and GDF10

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_004953.1	Gene:	GDF10 / 2662	HGNCID:	4215	Length:	478	Species:	Homo sapiens

Alignment Length:	126	Identity:	40/126 - (31%)
Similarity:	65/126 - (51%)	Gaps:	9/126 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   461 MQNRRRKSRQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQA 525
            ||..|||...:..:        |.|.:|.:.|.||||:.||:.|:.::||:|.|:|.........
Human   362 MQKARRKQWDEPRV--------CSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVR 418

  Fly   526 ASHHSSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGCR 586
            .|:|::|..|:...|....:. .|||...:.:||.::.:|.:....:|..|||.|::|.||
Human   419 PSNHATIQSIVRAVGIIPGIP-EPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	33/103 (32%)
GDF10	NP_004953.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	266..319
GDF10	NP_004953.1	TGF_beta	374..477	CDD:278448	33/111 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910