Protein Alignment daw and Gdf5

DIOPT Version :10

• Sequence 1: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_001385590.1
• Gene: Gdf5 / 252835
• RGDID: 620102
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 405
• Identity: 91/405 - (22%)
• Similarity: 167/405 - (41%)
• Gaps: 73/405 - (18%)

  Fly   202 QQPETPIEPELPLGERNIT-----ISVKSSAGGCPKCESNRQVEHITEEQLTHLRIEFV------ 255
            ::|.||.||:.|.....||     :|:..:.....:...|..|:  .|..|.:....|:
  Rat   144 REPGTPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVK--LEAGLANTITSFIDKGQDD 206

  Fly   256 KQQILEKLRLKESPKVSAVELPKPIFDGMTLSHPDDSTKNKELDDYYARTSKKFILLNRE--EVE 318
            :..::.|.|....  :||:|.     ||: |.......:.|.||     .:|..:..:..  :::
  Rat   207 RGPVVRKQRYVFD--ISALEK-----DGL-LGAELRILRKKPLD-----VAKPAVPSSGRVAQLK 258

  Fly   319 CNRARDGKSNPSMCFTFKIDDADAEGFDVSTAVLW-LFKNKQNRTDTASVNSTSAQQTIVVSEVE 382
            .:....|:...::.....:...|..|::|..  :| ||:|.:|          |||..:.:...|
  Rat   259 LSSCPSGRQPAALLDVRSVPGLDGSGWEVFD--IWKLFRNFKN----------SAQLCLELEAWE 311

  Fly   383 VDQQKDSKYLS---AAKTIAIQSV-NVQDEWMKIDIEWPIKHWISGHELSHLIQITCGGCDVSDM 443
            ..:..|.:.|.   ||:.:..::: .|.....|.|:            ..:.|:...|..|.:..
  Rat   312 RGRAVDLRGLGFERAARQVHEKALFLVFGRTKKRDL------------FFNEIKARSGQDDKTVY 364

  Fly   444 EEIISVDKDYRPFIVIDMQNRRRKSRQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYN 508
            |.:.|..:..|    ..:.||:.| |..:::.     ..|.|:.|:::|:|:||.:||:.|..|.
  Rat   365 EYLFSQRRKRR----APLANRQGK-RPSKNLK-----ARCSRKALHVNFKDMGWDDWIIAPLEYE 419

  Fly   509 AYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVP--CCTAKQYSSLQLVVMDSSNTAT 571
            |:.|.|.|..........::|:.|..::::...    |..|  ||...:.|.:.::.:||:|...
  Rat   420 AFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDP----ESTPPTCCVPTRLSPISILFIDSANNVV 480

  Fly   572 VKTLPNMVVESCGCR 586
            .|...:|||||||||
  Rat   481 YKQYEDMVVESCGCR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	32/103 (31%)
Gdf5	NP_001385590.1	Treacle	34..>146	CDD:460967	0/1 (0%)
		TGFb_propeptide	139..>290	CDD:480997	30/162 (19%)
		TGF_beta_GDF5	393..495	CDD:381669	33/105 (31%)