DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and Gdf6

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_038554.1	Gene:	Gdf6 / 242316	MGIID:	95689	Length:	454	Species:	Mus musculus

Alignment Length:	126	Identity:	36/126 - (28%)
Similarity:	63/126 - (50%)	Gaps:	12/126 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 NRRRKSRQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAAS 527
            :|..|...|:|      ...|.|:.|:::|:::||.:||:.|..|.||.|.|.|..........:
Mouse   339 SRHGKRHGKKS------RLRCSRKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLEPT 397

  Fly   528 HHSSIMKILSTSGANKSLELVP--CCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGCR 586
            :|:.|..::::.....:    |  ||...:.:.:.::.:|:.|....|...:|||||||||
Mouse   398 NHAIIQTLMNSMDPGST----PPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	29/105 (28%)
Gdf6	NP_038554.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..93
		TGFb_propeptide	75..284	CDD:279078
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..350		4/16 (25%)
		TGF_beta	352..453	CDD:278448	29/104 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810