Protein Alignment daw and Lefty1

DIOPT Version :10

• Sequence 1: NP_523461.1
• Gene: daw / 33474
• FlyBaseID: FBgn0031461
• Length: 586
• Species: Drosophila melanogaster
• Sequence 2: NP_034224.1
• Gene: Lefty1 / 13590
• MGIID: 107405
• Length: 368
• Species: Mus musculus
• Alignment Length: 429
• Identity: 97/429 - (22%)
• Similarity: 153/429 - (35%)
• Gaps: 149/429 - (34%)

  Fly   198 LDLDQQP---ETPIE-PELPLGERNITISV-----KSSAGGCPKCESNRQV--EHITEEQLTHLR 251
            |.|||.|   :..:| ..:|...|...:::     .|.:.|....::.|:|  ..:..|..|||.
Mouse    35 LQLDQPPVLDKADVEGMVIPSHVRTQYVALLQHSHASRSRGKRFSQNLREVAGRFLVSETSTHLL 99

  Fly   252 IEFVKQQ-------ILEKLRLKESPKVSAVELPKPIFDGMTLSHPDDSTKNKELDDYYARTSKKF 309
            :..::|:       :...|||.:.|      :|:...           .:.|.|..:.||.
Mouse   100 VFGMEQRLPPNSELVQAVLRLFQEP------VPRTAL-----------RRQKRLSPHSARA---- 143

  Fly   310 ILLNREEVECNRARDGKSNPSMCFTFK---IDDADAEGFDVSTAV-LWLFKNKQNRTDTASVNST 370
                |..:|..|.||..||.:.....:   |.::..:.|||:.|| .|
Mouse   144 ----RVTIEWLRFRDDGSNRTALIDSRLVSIHESGWKAFDVTEAVNFW----------------- 187

  Fly   371 SAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQSVNVQDE------WMKIDIEWPIKHWISGHELSH 429
                          ||     ||..:...:..|:||.|      |             |.|:|..
Mouse   188 --------------QQ-----LSRPRQPLLLQVSVQREHLGPGTW-------------SSHKLVR 220

  Fly   430 L-IQITCGGCDVSDME-EIISVD-KDYRPFIVIDMQNRRRKSRQKRSINC------SSGMTECCR 485
            . .|.|..|....:.: |:.::| |||      ..|.           ||      :.| |.|||
Mouse   221 FAAQGTPDGKGQGEPQLELHTLDLKDY------GAQG-----------NCDPEAPVTEG-TRCCR 267

  Fly   486 EHLYISFRDIGWS-NWILKPEGYNAYFCRGSCSSVASVTQAASHHSSIMKILSTSGANKSLELVP 549
            :.:|:..:.:.|: ||||:|.|:..|.|.|||..:.         .|:.......|..:
Mouse   268 QEMYLDLQGMKWAENWILEPPGFLTYECVGSCLQLP---------ESLTSRWPFLGPRQ------ 317

  Fly   550 CCTAKQYSSLQLVVMDSSNTAT---VKTLPNMVVESCGC 585
             |.|.:.:||.::|.......|   |.:||||.|::|.|
Mouse   318 -CVASEMTSLPMIVSVKEGGRTRPQVVSLPNMRVQTCSC 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_523461.1	TGF_beta_INHB	483..585	CDD:381630	31/105 (30%)
Lefty1	NP_034224.1	TGFb_propeptide	<43..203	CDD:480997	40/220 (18%)
		TGF_beta_LEFTY1_2	264..355	CDD:381636	31/106 (29%)