DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and Bmp3

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	NP_001297606.1	Gene:	Bmp3 / 110075	MGIID:	88179	Length:	470	Species:	Mus musculus

Alignment Length:	373	Identity:	66/373 - (17%)
Similarity:	119/373 - (31%)	Gaps:	144/373 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 NITISVKSSAGGCPK---CESNRQVEHI------------TEEQLTHLRIEFVK----------- 256
            ||::|       ||:   |..:.|.:||            ..:.|.||.::.|:
Mouse   139 NISLS-------CPEPQGCSHHTQRQHIQIDLSAWILKSNQSQLLGHLSVDVVRPYRDSVSWLSK 196

  Fly   257 --QQILEKLRLKESPKVS------AVELPKPIF-----------DGMTLSHPDDSTKNKELD-DY 301
              .|:|.|.:..|...:.      |.||||.:.           :...:|.|:....:.:.. |:
Mouse   197 DITQLLRKAKQNEEFLIGFNITSRAHELPKRMLFFPEPYILVYANDAAISEPESVVSSLQRHRDF 261

  Fly   302 YARTSKKFILLNREEVECNRARDGKSNPSMCFTFKIDDADAEGFDVSTAVLW----LFKNKQNRT 362
            .|.|..:.....||.:...|.:  |.:..:....:.::.....:.......|    .:|:.|.:.
Mouse   262 TAGTGPRLDSHVREALSVERRK--KRSTGILLPLQNNELPGAEYQYKEEGAWEERKPYKSLQTQP 324

  Fly   363 DTASVNSTSAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQSVNVQDEWMKIDIEWPIKHWISGHEL 427
            ...|.|...             |:|.|                                   |:.
Mouse   325 PEKSRNKKK-------------QRKGS-----------------------------------HQK 341

  Fly   428 SHLIQITCGGCDVSDMEEIISVDKDYRPFIVIDMQNRRRKSRQKRSINCSSGMTECCREHLYISF 492
            ...:|..                           :...:|:|:|:.:.    ...|.|.:|.:.|
Mouse   342 GQTLQFD---------------------------EQTLKKARRKQWVE----PRNCARRYLKVDF 375

  Fly   493 RDIGWSNWILKPEGYNAYFCRGSCS----SVASVTQAASHHSSIMKIL 536
            .|||||.||:.|:.::|::|.|:|.    .||:.  ||:.|..::..|
Mouse   376 ADIGWSEWIISPKSFDAFYCSGACQFPMPKVAAA--AAALHLVLISFL 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	32/248 (13%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	22/60 (37%)
Bmp3	NP_001297606.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..53
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	314..349		9/109 (8%)
		TGF_beta	364..>424	CDD:278448	22/60 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910