DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and nodal5

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_002945280.2	Gene:	nodal5 / 100495007	XenbaseID:	XB-GENE-483267	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	186	Identity:	45/186 - (24%)
Similarity:	78/186 - (41%)	Gaps:	36/186 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   432 QITCGGCDVSD--MEEIISVDK---------------DYRPFIVIDMQNR----RRKSRQKRSIN 475
            :|:|.|. :|:  |..:.|.||               :...:::.:...|    ||..|.:.::|
Frog   204 KISCNGL-LSERIMLMVFSTDKPSSKLTGSTSLIETAESSKYVITEADTRETGKRRHRRNRYALN 267

  Fly   476 -----------CSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSSVASVTQAASHH 529
                       ...|.|.|.|..:.:.|..||||:.|:.|:.:|||.|.|||....:.....::|
Frog   268 SIIRSSFHSQPVGDGKTLCRRVDMIVDFEKIGWSDRIIYPKRFNAYRCEGSCPIPLNENFKPTNH 332

  Fly   530 SSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            :.|..::  :..|......|.|...:...|.: :|...:...:|...:|:||.|||
Frog   333 AYIKSLV--NHFNPGRVECPSCIPVKMRPLSM-LMYEGDEIVLKHHEDMIVEECGC 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	8/42 (19%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	29/103 (28%)
nodal5	XP_002945280.2	TGFb_propeptide	51..186	CDD:366248
nodal5	XP_002945280.2	TGF_beta_NODAL	284..385	CDD:381637	29/103 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910