DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and inhbc.2

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_002939474.1	Gene:	inhbc.2 / 100494560	XenbaseID:	XB-GENE-1217521	Length:	354	Species:	Xenopus tropicalis

Alignment Length:	390	Identity:	96/390 - (24%)
Similarity:	173/390 - (44%)	Gaps:	71/390 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 ITISVKSSAGGCPKCES-NRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVSAVELPKPIFD 282
            :||.:..||.....|.: .:||....|:::.   .|..|:.||.||.||:.||:|.....:.:..
Frog    12 VTIQISLSASSSSGCSTFRKQVGAQNEKEML---FEMAKKNILSKLHLKQRPKISHTISREALAQ 73

  Fly   283 GM----------TLSHPDDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKSNPSMCFTFKI 337
            .:          .||..:.:   :|||     :.:.:.:::..::|.::|    |...:.|....
Frog    74 ALLRLNIRVQEDLLSSREQA---EELD-----SDQDYEVISFADIESSQA----SQTILHFHLSA 126

  Fly   338 DDADAEGFDVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQS 402
            :.....  ::..|.|||:           :.|..:::..:.....:.::|.|       |..|..
Frog   127 EKGTYR--EIHNAALWLY-----------LQSDPSKKLAIQITTSLAKEKSS-------TEMIHR 171

  Fly   403 VNVQDEWMKIDIEWPIKHWISGHELSHLIQITCGGC-------DVSDMEEIISVDKDYRPFIVID 460
            ..|:..|..:.:....:..:...|.:..:.:.|..|       ::||.:         |||:|:.
Frog   172 EIVRSGWYTLPLPMLTQAALGDGEENIYLYLECLNCTGQPVIRNISDAQ---------RPFLVVK 227

  Fly   461 MQNRRRKSRQKRSI-NCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSC----SSVA 520
            ..|:|...|.:|.| .|||.:..|||::.||.|::|||::||:.|||||..:|.|.|    :.|.
Frog   228 AHNQREDHRFRRHITECSSDVDMCCRKNFYIDFKEIGWTDWIISPEGYNMNYCEGRCPVHLARVP 292

  Fly   521 SVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            .:  |||.|::|:.::..:....|..  .||...:...|.|:..|..|:.....:|:|:||||||
Frog   293 GI--AASSHTAILSLIKANNLYASFS--SCCVPTKRRPLSLLYFDMYNSIVKTDIPDMIVESCGC 353

Fly 586 585
Frog 354 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	40/230 (17%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	38/107 (36%)
inhbc.2	XP_002939474.1	TGFb_propeptide	50..226	CDD:366248	37/216 (17%)
inhbc.2	XP_002939474.1	TGF_beta_SF	251..354	CDD:394804	40/107 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm47597
Panther	1	1.100	-	-	LDO	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020