DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and inhbc.1

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_002939470.1	Gene:	inhbc.1 / 100493888	XenbaseID:	XB-GENE-494358	Length:	367	Species:	Xenopus tropicalis

Alignment Length:	373	Identity:	97/373 - (26%)
Similarity:	168/373 - (45%)	Gaps:	57/373 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 CPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVS-------------AVELPKPIF 281
            ||.|          ..|...:.:|..|||||:||.|||.|.::             .:.|.||..
Frog    34 CPSC----------GVQDKEVMMELAKQQILQKLHLKERPNITHPVPRGAVANALRRLHLNKPRM 88

  Fly   282 DGMTLS-HPDDSTKNKELDDYYARTSKKFILLNREEVECNRARDGKSNPSMCFTFKIDDADAEGF 345
            :|:..| :.|.:|:|.|.|      .:.:.:::..|.|.:    .:.:.::.|.|..|  ..:..
Frog    89 EGLFGSINWDSNTENTETD------QQSYEIISFAETEYS----NEISTTLNFQFTRD--REQST 141

  Fly   346 DVSTAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQQKDSKYLSAAKTIAIQSVNVQDEWM 410
            .|..|.|||| .|.|||         :||...:....|.:....:.|.:.|.|..:...    |.
Frog   142 HVLQAHLWLF-FKANRT---------SQQNETIRLYLVQEANSRRILISEKLIEPRWTG----WQ 192

  Fly   411 KIDIEWPIKHWISGHELSHLIQITCGGCDVSDMEEIISVDKDYRPFIVIDMQ-NRRRKSRQKRSI 474
            ...::..::.:..|...|..:::.|.||  .|...:|:::..::||:|...: :.:.....|||:
Frog   193 TFSLKSTLQAFFDGGNKSLQLELNCEGC--QDAPVLINLNDSHQPFLVAQAKVHEQSHHATKRSL 255

  Fly   475 NCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCSS--VASVTQAASHHSSIMKILS 537
            ||......|||:..|:.|:||||::||:|||||...:|.|.|..  ..:...|||.|:::..::.
Frog   256 NCDQNSNLCCRKDYYVDFKDIGWNDWIIKPEGYQINYCMGLCPMHIAGAPGMAASFHTTVFNLIK 320

  Fly   538 TSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            .:....::.  .||...:...|.::..|.:|......:.:|:||:|||
Frog   321 ANNIQNAVN--SCCVPTKRRPLSMLYFDRNNNILKTDIADMIVEACGC 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	54/227 (24%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	32/105 (30%)
inhbc.1	XP_002939470.1	TGFb_propeptide	41..239	CDD:366248	53/225 (24%)
inhbc.1	XP_002939470.1	TGF_beta_INHBC_E	264..367	CDD:381676	34/105 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm47597
Panther	1	1.100	-	-	O	PTHR11848
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.110