DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and gdf5

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_002662587.1	Gene:	gdf5 / 100334210	ZFINID:	ZDB-GENE-990415-39	Length:	474	Species:	Danio rerio

Alignment Length:	131	Identity:	43/131 - (32%)
Similarity:	71/131 - (54%)	Gaps:	13/131 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   462 QNRRRKS---RQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFCRGSCS-SVASV 522
            |.|.|::   |.|:.|  .:....|.|:.|:::|:::||.:||:.|..|.|:.|.|.|. .:.|.
Zfish   351 QRRMRRAPLPRGKKPI--KNPKQRCNRKQLHVNFKEMGWDDWIIAPLEYEAFHCDGVCDFPIRSH 413

  Fly   523 TQAASHHSSIMKILSTSGANKSLELVP--CCTAKQYSSLQLVVMDSSNTATVKTLPNMVVESCGC 585
            .:..:|  :|::.|..|...:|   .|  ||...:.|.:.::.:||:|....|...:||||||||
Zfish   414 LEPTNH--AIIQTLMNSMDPRS---TPPTCCVPTRLSPISILYIDSANNVVYKQYEDMVVESCGC 473

  Fly   586 R 586
            |
Zfish   474 R 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	34/106 (32%)
gdf5	XP_002662587.1	TGFb_propeptide	138..320	CDD:279078
gdf5	XP_002662587.1	TGF_beta	371..473	CDD:278448	34/106 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810