DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment daw and inhba

DIOPT Version :9

Sequence 1:	NP_001259967.1	Gene:	daw / 33474	FlyBaseID:	FBgn0031461	Length:	586	Species:	Drosophila melanogaster
Sequence 2:	XP_002933452.1	Gene:	inhba / 100038114	XenbaseID:	XB-GENE-491002	Length:	411	Species:	Xenopus tropicalis

Alignment Length:	400	Identity:	98/400 - (24%)
Similarity:	168/400 - (42%)	Gaps:	58/400 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 SSAGGCPKCESNRQVEHITEEQLTHLRIEFVKQQILEKLRLKESPKVSAVELPKPIFDGMTLSH- 288
            ||...||.|...|..:.:...|..  .:|.||:.||..|.|::.|.::.......:.:.:...|
Frog    30 SSVNDCPSCALARFQKDVPSSQSD--MVEAVKKHILNMLHLRDRPNITQTVPKAALLNAIKKLHV 92

  Fly   289 ---PDDSTKNKELDDYYA-RTSKKFILLNREEVECNRARDGKSNPS-MCFTFKIDDADAEGFDVS 348
               .||.  ..:::|..| |.....|.....|:    ....:|.|| ....|:|....:....:.
Frog    93 GKVGDDG--QVQIEDVIAGRAEMNEISEQTSEI----ITFAESGPSKKILRFEISKEGSNFLIIG 151

  Fly   349 TAVLWLFKNKQNRTDTASVNSTSAQQTIVVSEVEVDQ--QKDSKYLSAAKTIAIQSVNVQDE-WM 410
            .|.||||      ...:..|.:.|:.||.:..::..|  |:.|:...:...||.:.|:.:.. |.
Frog   152 EADLWLF------LKLSKANRSRAKLTIRLYHLQRGQKDQRGSENNKSELLIAEKVVDTRKSGWH 210

  Fly   411 KIDIEWPIKHWISGHELSHLIQITCGGCD-----------------------VSDMEEIISVDKD 452
            ...|...|:..::..:.:..|::.|..|.                       .|.:||  ..::.
Frog   211 TFPIAGSIQRLLNHGKSTIDIRVACDQCQEAGATPVLLGKRKKKDDEDKEAGASGVEE--EKEQS 273

  Fly   453 YRPFIVI-----DMQNRRRKSRQKRSINCSSGMTECCREHLYISFRDIGWSNWILKPEGYNAYFC 512
            :|||::|     |....|||   ||.:.|...::.||::|.|:||:||||::||:.|.||:|.:|
Frog   274 HRPFLMIVARQTDEHPHRRK---KRGLECDGKVSICCKKHFYVSFKDIGWNDWIIAPPGYHANYC 335

  Fly   513 RGSCSS--VASVTQAASHHSSIMKILSTSGANKSLELVPCCTAKQYSSLQLVVMDSSNTATVKTL 575
            .|.|.|  ..:...:.|.||:::......|.:....:..||...:..::.::..|.......|.:
Frog   336 EGDCPSHFAGTTGSSLSFHSTVINQYRLRGQSPFTSIKSCCVPSKLRAMSMLYYDDGQNIIKKDI 400

  Fly   576 PNMVVESCGC 585
            .||:||.|||
Frog   401 QNMIVEECGC 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
daw	NP_001259967.1	TGFb_propeptide	244..458	CDD:279078	49/245 (20%)
daw	NP_001259967.1	TGF_beta	481..585	CDD:278448	33/105 (31%)
inhba	XP_002933452.1	TGFb_propeptide	56..278	CDD:366248	47/235 (20%)
inhba	XP_002933452.1	TGF_beta_INHBA	304..411	CDD:381674	34/106 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm47597
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.020