Protein Alignment Syt1 and SYTL5

DIOPT Version :9

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001156806.1
• Gene: SYTL5 / 94122
• HGNCID: 15589
• Length: 752
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 118/545 - (21%)
• Similarity: 201/545 - (36%)
• Gaps: 150/545 - (27%)

  Fly     3 PNAKSETDAKP--EAEPAPAS-------------EPAADL---ESVDQKLEETHH---------- 39
            |.:.......|  ::.|||::             |.:.||   |...|:|.::|.
Human   248 PKSSRSNGVTPGTQSSPAPSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPSIA 312

  Fly    40 ----SKFREVDRQE---QEVLAEKAAEAASQRIAQVE-STTRSATTEAQESTTTAVPVIKKIEHV 96
                |...:..|.|   .|...|.:.:..|.|...|. :..:.:..|.:||....|.
Human   313 VSGTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESIDALVS-------- 369

  Fly    97 GEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGV--------- 152
            .::.|......:||.|                             .::.|..:|..
Human   370 SQLSTNTHRLASGLST-----------------------------SSQAGSDRKWTYLNVPDADS 405

  Fly   153 DMKSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAE 217
            |..|:..:.|.|              :|.||..:.:..   |.:...:.|.:.:..|.:.|....
Human   406 DTTSLNSMMSVY--------------SETGDYGNVKVS---GEILLHISYCYKTGGLYIFVKNCR 453

  Fly   218 ELPALD-MGGTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFA 279
            .|...| ....:|.|||.||||||.:  |.:||:...| :|.||||..: ::.:.....:||..:
Human   454 NLAIGDEKKQRTDAYVKSYLLPDKSRNNKRKTKIRTGT-NPEFNETLKY-TISHTQLETRTLQLS 516

  Fly   280 IFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEW---RDLVSVEGEGGQEKLGDICFSLRYVP---- 337
            ::.:|||.::..:|||::|..:.:.....:||   :..|....:.|.:..|::...|||:|
Human   517 VWHYDRFGRNSFLGEVEIPFDSWNFENPTDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPEEN 581

  Fly   338 -------------------------TAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLK 377
                                     :.|.|.|.|.|||||..:..||.||.:||..::.:..:..
Human   582 LMLPPEQLQGNKTFKKGKKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKAT 646

  Fly   378 KKKTSIKKCTLNPYYNESFSFE-VPFEQIQKICLVVTVVDYDRI-------------GTSEPIGR 428
            |.||.:.|.::||.:|.:|.|. :..:.|:.:||.:|:.|.:..             |:....|:
Human   647 KHKTLVIKKSVNPQWNHTFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGK 711

  Fly   429 CILGCMGTGTELRHWSDMLASPRRP 453
            .:......|.|.|.|..|..:|..|
Human   712 NVDWMDSQGEEQRLWQKMANNPGTP 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	27/166 (16%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	36/129 (28%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	43/171 (25%)
SYTL5	NP_001156806.1	PHD_SF	11..123	CDD:328929
		FYVE_Slp5	62..108	CDD:277305
		CEP170_C	<159..>309	CDD:317681	12/60 (20%)
		C2A_SLP-4_5	429..552	CDD:175995	36/127 (28%)
		C2B_SLP_1-2-3-4	566..744	CDD:175987	43/171 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810