DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Syt1 and SYTL4

DIOPT Version :9

Sequence 1:NP_523460.2 Gene:Syt1 / 33473 FlyBaseID:FBgn0004242 Length:474 Species:Drosophila melanogaster
Sequence 2:NP_001357091.1 Gene:SYTL4 / 94121 HGNCID:15588 Length:676 Species:Homo sapiens


Alignment Length:554 Identity:138/554 - (24%)
Similarity:230/554 - (41%) Gaps:143/554 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 ESVDQKLEETHHSKFREV--------DRQ-EQEVLAEKAAEAASQRIAQVESTTRSATTEAQEST 83
            |:|.|.|  .|.::..::        :|| |..||.|.....:.:...:.||.:..:.|...:||
Human   150 ETVGQSL--LHQTQMGDIWPGRKIIQERQKEPSVLFEVPKLKSGKSALEAESESLDSFTADSDST 212

  Fly    84 TTAVPVIKKIEHVGEVVTEVIAERTGL-PTWGVVAI-------------IILVFLVVFGIIFFCV 134
            :....:                :::|| |.|..::.             ..:||:....:||   
Human   213 SRRDSL----------------DKSGLFPEWKKMSAPKSQVEKETQPGGQNVVFVDEGEMIF--- 258

  Fly   135 RRFLKKRRTKDGKGKKGVDMKSVQL------LGSAYKE--KVQPDMEELTENAEEGDEED----- 186
            ::..:|........|..:|::...:      ||...|.  .:..|||      ||.:|||     
Human   259 KKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGLNVDME------EEEEEEDIDHLV 317

  Fly   187 KQSEQKL---------------------------------GRLNFKLEYDFNSNSLAVTVIQAEE 218
            |...|||                                 ||:.|.|:|:..:.||.|.|.:..:
Human   318 KLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRIAFSLKYEQQTQSLVVHVKECHQ 382

  Fly   219 LPALDMG-GTSDPYVKVYLLPDKKK--KFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAI 280
            |...|.. ..|:||||.||||||.:  |.:|.:.|.|::|:::||..:: :|.:....:||.|::
Human   383 LAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTINPLYDETLRYE-IPESLLAQRTLQFSV 446

  Fly   281 FDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDL---VSVEGEGG-QEKLGDICFSLRYVPTA-- 339
            :...||.::..:||.::.:.:..|.:.::....|   :|.|...| ....|::..||:|:|.:  
Human   447 WHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPLHGKISAESPTGLPSHKGELVVSLKYIPASKT 511

  Fly   340 --------------GKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNP 390
                          |:|.|.|.|||||.....||.||.:||..::....:..|:||.:.|.||||
Human   512 PVGGDRKKSKGGEGGELQVWIKEAKNLTAAKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNP 576

  Fly   391 YYNESFSFE-VPFEQIQKICLVVTVVDYDRIGTSEPIG----------------RCILGCMGTGT 438
            :||.:|.:. |..|.:|.:||.:||.|.:.:.:::.:|                .|:| |..|..
Human   577 HYNHTFVYNGVRLEDLQHMCLELTVWDREPLASNDFLGGVRLGVGTVNIQPILIECLL-CARTRG 640

  Fly   439 ELRHWSDMLASPRRPIAQ-WHTLKDPEETDEILK 471
            .|...:||......|..| .|.|    .|.:|.|
Human   641 RLSSCTDMCTDKCDPDCQELHNL----PTKKIYK 670

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Syt1NP_523460.2 Podoplanin 5..136 CDD:283467 24/130 (18%)
C2A_Synaptotagmin-1-5-6-9-10 192..316 CDD:176031 41/162 (25%)
C2B_Synaptotagmin-1 326..461 CDD:176047 50/168 (30%)
SYTL4NP_001357091.1 FYVE_2 8..121 CDD:308117
FYVE_Slp4 58..107 CDD:277303
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 199..243 8/59 (14%)
C2A_SLP-4_5 357..481 CDD:175995 38/124 (31%)
C2B_SLP_1-2-3-4 496..>622 CDD:175987 40/125 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1028
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.