DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt1 and SYTL3

DIOPT Version :9

Sequence 1:	NP_523460.2	Gene:	Syt1 / 33473	FlyBaseID:	FBgn0004242	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001229313.1	Gene:	SYTL3 / 94120	HGNCID:	15587	Length:	610	Species:	Homo sapiens

Alignment Length:	502	Identity:	108/502 - (21%)
Similarity:	191/502 - (38%)	Gaps:	108/502 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPNAKSETDAKPEAEPAPASEPAADLESVDQKLEE------THHSKFREVDRQEQEVLAEKAAE 59
            :||.....::::....|....| .......::.:|.      ||   .:::.:.:.::.:||...
Human   154 VPPTPPPVSESQCSRSPGRLQE-FGQFRGFNKSVENLFLSLATH---VKKLSKSQNDMTSEKHLL 214

  Fly    60 AASQRIAQVESTTRSATTEAQESTT---TAVPVIKKI-EHVGEVVTEVIAERTGLPTWGVVAIII 120
            |...|....::..||.:..|...||   :|..::|.: :...:..|..|.::..||:....:.|.
Human   215 ATGPRQCVGQTERRSQSDTAVNVTTRKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAPSTIF 279

  Fly   121 LVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDMKSVQLLGSAYKEKVQPDMEELTENAEEGDEE 185
                                    .|..:.|    |:..:.|...|....|...:|
Human   280 ------------------------SGGFRHG----SLISIDSTCTEMGNFDNANVT--------- 307

  Fly   186 DKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEELP-ALDMGGTSDPYVKVYLLPDKKK--KFETK 247
                    |.:.|.:.|.|.::||.:.:...:.|. ..:.....:||||.|||||:..  |.:|.
Human   308 --------GEIEFAIHYCFKTHSLEICIKACKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTG 364

  Fly   248 VHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTID--------- 303
            |.|.|:.|.|.||..::..| |..:.:.|..:::.....::...:|||.:||.|.|
Human   365 VQRNTVDPTFQETLKYQVAP-AQLVTRQLQVSVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSF 428

  Fly   304 ----LAQTIEEWRDLVSVEGEGGQ-------------EKLGDICFSLRYVPTAGKLTVVILEAKN 351
                |....|::.|  ||....|:             .||.:...........|:|.:|:|.|||
Human   429 RWHPLRAKAEKYED--SVPQSNGELTVRAKLVLPSRPRKLQEAQEGTDQPSLHGQLCLVVLGAKN 491

  Fly   352 LKKMDVGGLSDPYVKIAI-MQNGKRLKKKKTSIKK--CTLNPYYNESFSFE-VPFEQIQKICLVV 412
            |.....|.|:. :||..: :.:.::|:.|...::|  |   |.:..||.|. |...|:::..|.:
Human   492 LPVRPDGTLNS-FVKGCLTLPDQQKLRLKSPVLRKQAC---PQWKHSFVFSGVTPAQLRQSSLEL 552

  Fly   413 TVVDYDRIGTSEP-IGRCILGCMG--------TGTELRHWSDMLASP 450
            ||.|....|.::. :|...||..|        .......|..:|:||
Human   553 TVWDQALFGMNDRLLGGTRLGSKGDTAVGGDACSLSKLQWQKVLSSP 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	21/140 (15%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	38/139 (27%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	36/138 (26%)
SYTL3	NP_001229313.1	PHD_SF	8..123	CDD:328929
		FYVE_Slp3	60..108	CDD:277304
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..239		4/19 (21%)
		C2A_SLP-3	307..434	CDD:176038	36/144 (25%)
		C2B_SLP_1-2-3-4	448..610	CDD:175987	38/156 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810