Protein Alignment Syt1 and SYT12

DIOPT Version :9

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_024304534.1
• Gene: SYT12 / 91683
• HGNCID: 18381
• Length: 487
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 124/503 - (24%)
• Similarity: 218/503 - (43%)
• Gaps: 106/503 - (21%)

  Fly     3 PNAKSETDAKPEAEPAPASEPAADLESVDQKLEETH----------------------------- 38
            |..:.:|.|.|..|   .:..|||:.:||  :.|.|
Human    45 PGNEMKTKAPPVGE---VTVTAADIMAVD--VAEYHLSVIKSPPGWEVGVYAAGALALLGIAAVS 104

  Fly    39 ------------HSKFREVD-RQEQEVLAEKAAEAASQRIAQVESTTRSATTEAQESTTTAVPVI 90
                        .|.|...| |..|:...|..|||..:|:....:  :.|:|....|...::.:.
Human   105 LWKLWTSGSFPSPSPFPNYDYRYLQQKYGESCAEAREKRVPAWNA--QRASTRGPPSRKGSLSIE 167

  Fly    91 KKIEHVGEV-VTEVIAERTGLPTWGVVAIIILVFLVVFGIIFFCVRRFLKKRRTKDGKGKKGVDM 154
            ...|.:.|: ..|::.....|..:|.                      |:|.::.|       .:
Human   168 DTFESISELGPLELMGRELDLAPYGT----------------------LRKSQSAD-------SL 203

  Fly   155 KSVQLLGSAYKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEEL 219
            .|:..:.:.:.:                       :..||::...:|||..|::|.|.|:|.::|
Human   204 NSISSVSNTFGQ-----------------------DFTLGQVEVSMEYDTASHTLNVAVMQGKDL 245

  Fly   220 PALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYADAMNKTLVFAIFDFD 284
            ...:.......:::|.||||::....:::.|...|..|:|.|:....|.| ...|:|.|::|..|
Human   246 LEREEASFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSIPLDPTA-LEEKSLRFSVFGID 309

  Fly   285 RFSKHDQIGEVKVPLCTIDL-AQTIEEWRDLVSVEGEGGQEKLGDICFSLRYVPTAGKLTVVILE 348
            ...::...|.|::.|..:|| .|....|  |...:.....:.:|:|..||.|:|||.:||||:::
Human   310 EDERNVSTGVVELKLSVLDLPLQPFSGW--LYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVK 372

  Fly   349 AKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEVPFEQIQKICLVVT 413
            ||||...:....:||:||:.::|:|:::.||||::|:...||.:||:..|.||...:|.:.|.||
Human   373 AKNLIWTNDKTTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVT 437

  Fly   414 VVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLK 461
            |.:....|..:.:|..|:|...:|....||:.|||:.|||::.||.::
Human   438 VAESSSDGRGDNVGHVIIGPSASGMGTTHWNQMLATLRRPVSMWHAVR 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	29/173 (17%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	36/124 (29%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	54/134 (40%)
SYT12	XP_024304534.1	C2	218..329	CDD:326325	31/111 (28%)
		C2B_Synaptotagmin-12	350..485	CDD:176051	54/134 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820