Protein Alignment Syt1 and SYT8

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_001277261.2
• Gene: SYT8 / 90019
• HGNCID: 19264
• Length: 402
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 156/395 - (39%)
• Similarity: 223/395 - (56%)
• Gaps: 46/395 - (11%)

  Fly    84 TTAVPVIKKIEHVGEVVTEVIAERTGLPTW----GVVAIIILVFLVVFGIIFFCVRRFLKKRRTK 144
            |||:|         .::.:::| .|..|.|    |.:|..:|:...:......|.||..||.|.|
Human    31 TTAIP---------GLIPDLVA-GTPWPRWALIAGALAAGVLLVSCLLCAACCCCRRHRKKPRDK 85

  Fly   145 DGKGKKGVDMKSVQLLGSA----YKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFN 205
            :..|           ||||    ....||||::.|  .:..||      .|:.|.|...||:||.
Human    86 ESVG-----------LGSARGTTTTHLVQPDVDGL--ESSPGD------AQQWGCLQLSLEFDFG 131

  Fly   206 SNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYAD 270
            |..:.|.:.||.:|..   |||.|||.:|.:......:.||||||.||.|||:||..| .:|.|:
Human   132 SQEIRVGLRQAADLRP---GGTVDPYARVSVSTQAGHRHETKVHRGTLCPVFDETCCF-HIPQAE 192

  Fly   271 AMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRY 335
            ....||...:|:|.|||.|:.:||:::||.|:||...:|.|. |:........|::|::||||||
Human   193 LPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLEHWY-LLGPPAATQPEQVGELCFSLRY 256

  Fly   336 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEV 400
            ||::|:||||:|||:.|:.    ||::||||:.:|.|.::.||:||:.||.|..||:||:|:|.|
Human   257 VPSSGRLTVVVLEARGLRP----GLAEPYVKVQLMLNQRKWKKRKTATKKGTAAPYFNEAFTFLV 317

  Fly   401 PFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEE 465
            ||.|:|.:.||:.|.|......:||:|:..||...:|..|:||:||||..||||||.|.|:...|
Human   318 PFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHWADMLAHARRPIAQRHPLRPARE 382

  Fly   466 TDEIL 470
            .|.:|
Human   383 VDRML 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	19/80 (24%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	52/123 (42%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	68/134 (51%)
SYT8	NP_001277261.2	C2	120..233	CDD:472691	50/116 (43%)
		C2	248..377	CDD:472691	68/132 (52%)