Protein Alignment Syt1 and SYT8

DIOPT Version :9

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_011518757.1
• Gene: SYT8 / 90019
• HGNCID: 19264
• Length: 539
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 156/395 - (39%)
• Similarity: 223/395 - (56%)
• Gaps: 46/395 - (11%)

  Fly    84 TTAVPVIKKIEHVGEVVTEVIAERTGLPTW----GVVAIIILVFLVVFGIIFFCVRRFLKKRRTK 144
            |||:|         .::.:::| .|..|.|    |.:|..:|:...:......|.||..||.|.|
Human   168 TTAIP---------GLIPDLVA-GTPWPRWALIAGALAAGVLLVSCLLCAACCCCRRHRKKPRDK 222

  Fly   145 DGKGKKGVDMKSVQLLGSA----YKEKVQPDMEELTENAEEGDEEDKQSEQKLGRLNFKLEYDFN 205
            :..|           ||||    ....||||::.|  .:..||      .|:.|.|...||:||.
Human   223 ESVG-----------LGSARGTTTTHLVQPDVDGL--ESSPGD------AQQWGCLQLSLEFDFG 268

  Fly   206 SNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLPYAD 270
            |..:.|.:.||.:|..   |||.|||.:|.:......:.||||||.||.|||:||..| .:|.|:
Human   269 SQEIRVGLRQAADLRP---GGTVDPYARVSVSTQAGHRHETKVHRGTLCPVFDETCCF-HIPQAE 329

  Fly   271 AMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQEKLGDICFSLRY 335
            ....||...:|:|.|||.|:.:||:::||.|:||...:|.|. |:........|::|::||||||
Human   330 LPGATLQVQLFNFKRFSGHEPLGELRLPLGTVDLQHVLEHWY-LLGPPAATQPEQVGELCFSLRY 393

  Fly   336 VPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFEV 400
            ||::|:||||:|||:.|:.    ||::||||:.:|.|.::.||:||:.||.|..||:||:|:|.|
Human   394 VPSSGRLTVVVLEARGLRP----GLAEPYVKVQLMLNQRKWKKRKTATKKGTAAPYFNEAFTFLV 454

  Fly   401 PFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTLKDPEE 465
            ||.|:|.:.||:.|.|......:||:|:..||...:|..|:||:||||..||||||.|.|:...|
Human   455 PFSQVQNVDLVLAVWDRSLPLRTEPVGKVHLGARASGQPLQHWADMLAHARRPIAQRHPLRPARE 519

  Fly   466 TDEIL 470
            .|.:|
Human   520 VDRML 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Podoplanin	5..136	CDD:283467	12/55 (22%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	52/123 (42%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	68/134 (51%)
SYT8	XP_011518757.1	C2	257..370	CDD:301316	50/116 (43%)
		C2	385..514	CDD:301316	68/132 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1028
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D394604at33208
OrthoFinder	1	1.000	-	-		FOG0000025
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10024
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880